Table 5.

Estimates of PAF and heritability and 95% CI contributed by individual variants significantly associated with lung cancer in two GWAS conducted in Asian populations.

Variant1	PX1	OR	PÂF	ĥ2	${\widehat{h}}_{\text{L}}^2$
rs7086803	0.27	1.28 (1.21,1.35)	0.136 (0.104,0.165)	6.02e-05 (3.57e-05,8.93e-05)	0.0015
rs9387478	0.50	0.85 (0.81, 0.90)2	0.156 (0.102,0.199)	2.93e-05 (1.27e-05,4.79e-05)	0.0005
rs2395185	0.36	1.17 (1.11,1.23)	0.111 (0.074,0.146)	2.69e-05 (1.20e-05,4.65e-05)	0.0005
rs3817963	0.32	1.18 (1.12.1.24)	0.105 (0.072,0.152)	2.88e-05 (1.35e-05,4.86e-05)	0.0006

¹The calculation of PAF and heritability of rs7086803, rs9387478, and rs2395185 were based on the first GWAS of N = 7421 never-smoking female lung cancer cases and 6512 controls drawn from 14 studies from mainland China, South Korea, Japan and Singapore, Taiwan and Hong Kong; the calculation of PAF and heritability of rs3817963 were based on the second GWAS of lung carcinoma conducted in a Japanese population with a total of 6,029 cases and 13,535 controls. ²The reciprocal of the OR was used to calculate PAF.