Table 3.
Effect of MEMARB on serum and tissue inflammatory markers.
| Group | Caspase-1 |
MPO |
IL-1beta |
IL-18 |
|
|---|---|---|---|---|---|
| Serum (pg/ml) | Pancreas (pM/mg protein) | Pancreas (Units/mg protein) | Serum pg/ml | Serum pg/ml | |
| Normal Control | 12.6 ± 1.8 | 12.6 ± 1.5 | 2.16 ± 0.4 | 15.5 ± 2.6 | 200.5 ± 30.1 |
| MEMARB Control | 11.5 ± 1.3NS | 10.3 ± 1.2NS | 1.82 ± 0.2NS | 13.6 ± 2.1NS | 170 ± 21.6NS |
| EtOH + Cerulein | 21.5 ± 2.8* | 49.6 ± 5.2* | 3.98 ± 0.4* | 31.5 ± 4.5* | 360.5 ± 42* |
| EtOH + Cerulein + MEMARB | 14.3 ± 1.8* | 20.5 ± 2.8* | 2.56 ± 0.3* | 20.5 ± 3.1* | 240 ± 32* |
Data were analysed by one-way ANOVA followed by post-hoc Bonferroni test. Values are expressed as mean ± S.D. of 6 rats in each group. Statistical significance was calculated by comparing normal control vs. MEMARB control; Control vs. EtOH + Cerulein; EtOH + Cerulein vs. EtOH + Cerulein + MEMARB. *p = 0.000; NS non-significant.