Figure 3.

Comparison of ClinPred with Categorical Predictions Available from M-CAP, REVEL, and MetaLR

REVEL and ClinPred scores lower than 0.5 are defined as tolerant and greater than 0.5 as damaging. We show proportions of benign and pathogenic variants that were classified as tolerated (T, green) and damaging (D, pink). ClinPred had the best performance in finding as many pathogenic variants possible while minimizing the number of benign variants that are predicted as damaging both in ClinVarTest (A) and MouseVariSNP (B).