Table 1.
Prognostic accuracy of positive qSOFA, SIRS, qPELOD-2, and qSOFA-L scores for PICU transfer and/or mortality and prolonged hospital length of stay.
| Primary outcome: PICU transfer and/or mortality | Secondary outcome: Prolonged hospital LOS (≥7 days) | Comparison to AUROC qSOFA positive | ||
|---|---|---|---|---|
| Area under the curve (95% CI) | Area under the curve (95% CI) | P-value 1st outcome | P-value 2nd outcome | |
| qSOFA positive | 0.72 (0.57–0.86) | 0.53 (0.46–0.59) | – | – |
| SIRS positive | 0.64 (0.53–0.74) | 0.49 (0.44–0.54) | 0.23 | 0.82 |
| qPELOD-2 positive | 0.60 (0.45–0.76) | 0.51 (0.45–0.57) | 0.03 | 0.25 |
| qSOFA-lactate positive | 0.67 (0.50–0.84) | 0.56 (0.46–0.67) | < 0.01 | 0.58 |
| Primary outcome: PICU transfer and/or mortality | ||||
| Sensitivity (%) | Specificity (%) | Negative predictive value (%) | Positive predictive value (%) | |
| qSOFA positive | 50.0 | 93.3 | 98.0 | 22.5 |
| SIRS positive | 81.8 | 45.8 | 98.8 | 4.3 |
| qPELOD-2 positive | 22.2 | 98.7 | 97.4 | 36.4 |
| qSOFA-lactate positive | 58.3 | 76.3 | 95.5 | 17.5 |
| Secondary outcome: Prolonged hospital length of stay (≥7 days) | ||||
| Sensitivity (%) | Specificity (%) | Negative predictive value (%) | Positive predictive value (%) | |
| qSOFA positive | 5.8 | 89.0 | 21.6 | 64.5 |
| SIRS positive | 55.0 | 47.7 | 22.2 | 79.6 |
| qPELOD-2 positive | 1.0 | 97.3 | 22.3 | 57.1 |
| qSOFA-lactate positive | 21.2 | 65.9 | 30.2 | 54.5 |
| Prevalence PICU transfer and/or mortality | ||||
| Positive score (%) | Negative score (%) | Between group difference (%) | P-value | |
| qSOFA | 22.5 | 2.0 | 20.5 | < 0.01 |
| SIRS | 4.3 | 1.2 | 3.1 | 0.010 |
| qPELOD-2 | 36.4 | 2.6 | 33.8 | < 0.01 |
| qSOFA-lactate | 17.5 | 4.5 | 13.0 | 0.009 |