Table 3.
Correlation between change in performance on neuropsychological tests and log (lesion volume), forebrain and hippocampal volumes, covarying for age, education, number of vascular risk factors, duration of PD, percent change in UPDRS, postsurgical levodopa equivalence score, and time from surgery to postsurgical NP testing.
| White matter lesion | Left forebrain parenchyma | Right forebrain parenchyma | Left hippocampus | Right hippocampus | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total N | r | p‐value | r | p‐value | r | p‐value | r | p‐value | r | p‐value | |
| Attention | |||||||||||
| BTA | 35 *; 23 | −0.02 | 0.93 | 0.38 | 0.14 | 0.31 | 0.24 | 0.04 | 0.88 | 0.30 | 0.25 |
| Digit span | 36 *; 23 | 0.02 | 0.91 | −0.01 | 0.97 | −0.11 | 0.68 | −0.18 | 0.49 | 0.38 | 0.15 |
| Coding | 37 *; 25 | −0.28 | 0.13 | −0.27 | 0.28 | −0.27 | 0.27 | −0.10 | 0.70 | −0.02 | 0.92 |
| Executive Function | |||||||||||
| Stroop color‐word | 30 *; 19 | 0.01 | 0.96 | 0.38 | 0.23 | 0.40 | .020 | −0.08 | 0.80 | 0.03 | 0.93 |
| Stroop interference | 27 *; 17 | −0.02 | 0.94 | 0.59 | 0.07 | 0.55 | 0.10 | 0.32 | 0.36 | 0.27 | 0.45 |
| WSCT‐64 perseverative errors | 33 *; 20 | −0.01 | 0.97 | 0.03 | 0.93 | 0.16 | 0.60 | −0.40 | 0.18 | −0.37 | 0.21 |
| Memory | |||||||||||
| BVMT‐R delayed recall | 39 *; 26 | 0.03 | 0.88 | 0.00 | 0.99 | 0.03 | 0.90 | −0.33 | 0.17 | −0.13 | 0.60 |
| BVMT‐R discrimination index | 39 *; 26 | 0.08 | 0.64 | −0.12 | 0.61 | −0.09 | 0.73 | 0.01 | 0.96 | −0.20 | 0.40 |
| BVMT‐R total | 39 *; 26 | 0.05 | 0.77 | 0.12 | 0.63 | 0.19 | 0.44 | −0.33 | 0.17 | −0.09 | 0.71 |
| CVLT‐II long‐delay recall | 38 *; 25 | −0.04 | 0.83 | 0.22 | 0.38 | 0.14 | 0.58 | 0.18 | 0.48 | −0.11 | 0.66 |
| CVLT‐II recognition hits | 38 *; 25 | 0.05 | 0.81 | −0.07 | 0.79 | −0.08 | 0.75 | 0.26 | 0.30 | 0.48 | 0.04 |
| CVLT‐II total | 38 *; 25 | 0.03 | 0.87 | 0.39 | 0.11 | 0.35 | 0.16 | 0.19 | 0.45 | 0.04 | 0.88 |
| Verbal fluency | |||||||||||
| Animal naming | 36 *; 23 | −0.33 | 0.08 | 0.08 | 0.76 | 0.11 | 0.69 | 0.10 | 0.72 | 0.09 | 0.73 |
| Letter fluency | 38 *; 25 | −0.29 | 0.11 | 0.07 | 0.77 | 0.05 | 0.85 | 0.08 | 0.75 | 0.27 | 0.28 |
| Visuospatial function | |||||||||||
| Block design | 36 *; 24 | −0.44 | 0.02 | −0.13 | 0.63 | −0.14 | 0.59 | −0.18 | 0.49 | 0.20 | 0.45 |
| JOLO | 37 *; 24 | 0.13 | 0.48 | −0.14 | 0.6 | −0.16 | 0.55 | −0.08 | 0.75 | 0.02 | 0.93 |
*Total N for lesion volume analysis
Abbreviations: BTA, Brief Test of Attention; BVMT‐R, Brief Visual Memory Test‐Revised; CVLT‐II, California Verbal Learning Test‐II; JOLO, Judgement of Line Orientation; WCST‐64, Wisconsin Card Sorting Test‐64.