Table 4.
Baseline clincial information per subject category (extended assessments)
| Measure | HDGECs (N = 1,071) | Control (N = 463) | Manifest (N = 739) | Premanifest (N = 332) | Genotype Negative (N = 197) | Family Control (N = 266) |
|---|---|---|---|---|---|---|
| Extended clinical assessments | ||||||
| Stroop Interference (total correct) | ||||||
| n | 929 | 425 | 626 | 303 | 180 | 245 |
| Mean ± SD | 30.6 ± 14.8 | 42.5 ± 11.7 | 24.2 ± 11.8 | 43.9 ± 11.0 | 44.4 ± 12.3 | 41.0 ± 11.0 |
| Median (range) | 30.0 (0.0; 93.0) | 42.0 (0.0; 107.0) | 23.0 (0.0; 78.0) | 44.0 (13.0; 93.0) | 45.0 (0.0; 76.0) | 41.0 (1.0; 107.0) |
| Trail Making test Part A (total correct) | ||||||
| n | 799 | 408 | 519 | 280 | 179 | 229 |
| Mean ± SD | 24.3 ± 3.9 | 25.0 ± 0.2 | 23.9 ± 4.8 | 25.0 ± 0.0 | 25.0 ± 0.2 | 25.0 ± 0.1 |
| Median (range) | 25.0 (0.0; 25.0) | 25.0 (23.0; 27.0) | 25.0 (0.0; 25.0) | 25.0 (25.0; 25.0) | 25.0 (23.0; 27.0) | 25.0 (24.0; 25.0) |
| Trail Making test Part B (total correct) | ||||||
| n | 783 | 405 | 505 | 278 | 179 | 226 |
| Mean ± SD | 22.5 ± 10.3 | 24.7 ± 2.4 | 21.1 ± 12.6 | 24.8 ± 1.6 | 24.4 ± 3.5 | 24.9 ± 0.5 |
| MKedian (range) | 25.0 (0.0; 240.0) | 25.0 (0.0; 25.0) | 25.0 (0.0; 240.0) | 25.0 (7.0; 25.0) | 25.0 (0.0; 25.0) | 25.0 (18.0; 25.0) |
| Letter Verbal Fluency test (total correct) | ||||||
| n | 841 | 401 | 568 | 273 | 175 | 226 |
| Mean ± SD | 27.0 ± 15.8 | 40.6 ± 13.0 | 21.3 ± 13.3 | 38.9 ± 13.6 | 41.9 ± 14.3 | 39.7 ± 11.8 |
| Median (range) | 26.0 (0.0; 84.0) | 39.0 (0.0; 77.0) | 19.0 (0.0; 65.0) | 38.0 (10.0; 84.0) | 41.9 (0.0; 77.0) | 38.5 (13.0; 70.0) |
| MMSE: | ||||||
| n | 668 | 352 | 437 | 231 | 157 | 195 |
| Mean ± SD | 26.5 ± 3.8 | 28.9 ± 1.5 | 25.4 ± 4.2 | 28.5 ± 1.9 | 29.1 ± 1.5 | 28.7 ± 1.5 |
| Median (range) | 27.0 (0.0; 30.0) | 29.0 (19.0; 30.0) | 26.0 (0.0; 30.0) | 29.0 (16.0; 30.0) | 30.0 (19.0; 30.0) | 29.0 (24.0; 30.0) |
| HADS depression score | ||||||
| n | 672 | 341 | 442 | 228 | 157 | 184 |
| Mean ± SD | 5.7 ± 3.9 | 4.8 ± 3.4 | 6.3 ± 4.5 | 3.2 ± 3.3 | 2.6 ± 3.0 | 3.1 ± 2.6 |
| Median (range) | 5.0 (0.0; 19.0) | 4.0 (0.0; 16.0) | 6.0 (0.0; 21.0) | 3.0 (0.0; 20.0) | 2.0 (0.0; 15.0) | 3.0 (0.0; 14.0) |
| HADS anxiety score | ||||||
| n | 670 | 341 | 443 | 229 | 157 | 184 |
| Mean ± SD | 5.2 ± 4.4 | 2.9 ± 2.8 | 5.8 ± 4.1 | 5.5 ± 3.7 | 4.6 ± 3.6 | 5.0 ± 3.3 |
| Median (range) | 4.0 (0.0; 21.0) | 2.0 (0.0; 15.0) | 6.0 (0.0; 19.0) | 5.0 (0.0; 15.0) | 4.0 (0.0; 16.0) | 4.5 (0.0; 16.0) |
| SIS | ||||||
| n | 671 | 342 | 442 | 229 | 158 | 184 |
| Mean ± SD | 5.7 ± 4.4 | 4.0 ± 3.3 | 6.0 ± 4.5 | 5.3 ± 4.2 | 3.9 ± 3.7 | 4.2 ± 3.0 |
| Median (range) | 5.0 (0.0; 23.0) | 3.0 (0.0; 21.0) | 6.0 (0.0; 23.0) | 4.0 (0.0; 23.0) | 3.0 (0.0; 21.0) | 4.0 (0.0; 15.0) |