Table 1.
Demographic and Clinical Features in Recent Onset Parkinson's Disease
| Variable | Total (N = 1738) | Hoehn and Yahr Stage | Heterogeneity (P Value) | Trend (P Value) | ||
|---|---|---|---|---|---|---|
| 1 (N = 855) | 2 (N = 783) | 3 + (N = 100) | ||||
| Age (y) | 67.6 (9.3) | 66.1 (9.2) | 68.7 (9.0) | 71.8 (9.1) | <0.001a | <0.001a |
| Age at diagnosis (y) | 66.3 (9.2) | 64.9 (9.2) | 67.3 (9.0) | 70.3 (9.1) | <0.001a | <0.001a |
| Duration (y) | 1.3 (0.9) | 1.2 (0.9) | 1.4 (0.9) | 1.4 (1.0) | <0.001b | <0.001b |
| Male sex | 1132 (65.1%) | 539 (63.0%) | 540 (69.0%) | 53 (53.0%) | 0.001c | 0.88c |
| Drug naïve | 168 (9.7%) | 108 (12.6%) | 56 (7.2%) | 4 (4.1%) | 0.007 d | 0.001d |
| LEDD (mg) | 294 (205) | 264 (208) | 320 (202) | 353 (158) | <0.001d | <0.001d |
| MDS UPDRS 3 | 22.5 (12.1) | 16.8 (8.8) | 26.4 (11.3) | 40.1 (13.7) | <0.001d | <0.001d |
| Motor Subtype | ||||||
| Tremor dominant | 763 (46.9%) | 414 (51.7%) | 339 (46.2%) | 10 (10.8%) | ||
| PIGD | 652 (40.1%) | 273 (34.1%) | 306 (41.7%) | 73 (78.5%) | <0.001d | <0.001d |
| Indeterminate | 212 (13.0%) | 114 (14.2%) | 88 (12.0%) | 10 (10.8%) | 0.018d | 0.45d |
| SCOPA‐AUT total | 11.7 (7.0) | 10.7 (6.2) | 12.7 (7.6) | 13.5 (6.9) | <0.001d | <0.001d |
Eight cases with missing H&Y status are not shown; data are presented as mean and standard deviation or percentage.
LEDD, l‐dopa equivalent daily dose; MDS UPDRS 3, Movement Disorder Society Unified Parkinson's disease rating scale Part 3; PIGD, postural instability and gait difficulty; SCOPA‐AUT, scales for outcomes in Parkinson's disease—autonomic symptoms.
a
Adjusted for sex and disease duration.
b
Adjusted for sex and age.
c
Adjusted for age and disease duration.
d
Adjusted for sex, age, and disease duration.