Table 2.
Gastrointestinal and Urinary Disturbance in Relation to Motor Severity Grading in Recent Onset Parkinson's Disease (% with an Item Score ≥1)
| Variable | Total (N = 1738) (%) | Hoehn and Yahr Stage | Heterogeneity (P Value)a | Trend (P Value)a | ||
|---|---|---|---|---|---|---|
| 1 (N = 855) (%) | 2 (N = 783) (%) | 3 + (N = 100) (%) | ||||
| Gastrointestinal domain | 1437 (83.7) | 687 (81.1) | 659 (85.6) | 91 (91.0) | 0.091 | 0.033 |
| Swallowing/choking | 421 (24.3) | 199 (23.3) | 190 (24.3) | 32 (32.0) | 0.22 | 0.21 |
| Sialorrhea | 891 (51.4) | 387 (45.3) | 448 (57.5) | 56 (56.0) | 0.003 | 0.002 |
| Dysphagia | 349 (20.1) | 168 (19.7) | 156 (19.9) | 25 (25.0) | 0.62 | 0.74 |
| Early abdominal fullness | 361 (20.8) | 164 (19.2) | 168 (21.5) | 29 (29.0) | 0.095 | 0.035 |
| Constipation | 755 (43.6) | 335 (39.2) | 362 (46.5) | 58 (58.0) | 0.003 | <0.001 |
| Straining for defecation | 1017 (58.7) | 470 (55.1) | 486 (62.4) | 61 (61.0) | 0.12 | 0.12 |
| Fecal incontinence | 125 (7.2) | 59 (6.9) | 56 (7.2) | 10 (10.0) | 0.78 | 0.75 |
| Urinary domain | 1654 (96.6) | 815 (96.6) | 746 (96.8) | 93 (95.9) | 0.85 | 0.74 |
| Urinary urgency | 707 (40.8) | 329 (38.6) | 333 (42.7) | 45 (45.5) | 0.72 | 0.48 |
| Urinary incontinence | 500 (28.8) | 234 (27.4) | 228 (29.2) | 38 (38.0) | 0.57 | 0.41 |
| Incomplete emptying | 739 (42.6) | 342 (40.0) | 340 (43.5) | 57 (57.6) | 0.011 | 0.016 |
| Weak stream of urine | 717 (41.4) | 334 (39.1) | 339 (43.5) | 44 (44.9) | 0.59 | 0.30 |
| Frequency | 1371 (79.1) | 679 (79.6) | 617 (79.0) | 75 (75.0) | 0.71 | 0.69 |
| Nocturia | 1518 (87.5) | 736 (86.5) | 693 (88.5) | 89 (89.0) | 0.85 | 0.63 |
Eight cases with missing H&Y status are not shown.
a
Adjusted for age, sex, and disease duration.