Table 3.
Cardiovascular, Thermoregulatory, Pupillomotor, and Sexual Disturbance in Relation to Motor Severity Grading in Recent Onset Parkinson's Disease (% with an Item Score ≥1)
| Variable | Total (N = 1738) (%) | Hoehn and Yahr Stage | Heterogeneity (P Value)a | Trend (P Value)a | ||
|---|---|---|---|---|---|---|
| 1 (N = 855) (%) | 2 (N = 783) (%) | 3 + (N = 100) (%) | ||||
| Cardiovascular domain | 680 (39.6) | 315 (37.1) | 313 (40.4) | 52 (54.7) | 0.007 | 0.005 |
| Lightheaded when standing up | 580 (33.6) | 265 (31.1) | 270 (34.8) | 45 (46.4) | 0.007 | 0.004 |
| Lightheaded when standing for some time | 414 (23.9) | 187 (21.9) | 191 (24.4) | 36 (36.7) | 0.011 | 0.006 |
| Syncope | 48 (2.8) | 18 (2.1) | 26 (3.3) | 4 (4.0) | 0.30 | 0.14 |
| Thermoregulatory domain | 1174 (68.0) | 563 (66.1) | 539 (69.5) | 72 (72.0) | 0.19 | 0.078 |
| Hyperhidrosis during the day | 333 (19.2) | 162 (19.0) | 149 (19.1) | 22 (22.0) | 0.21 | 0.088 |
| Hyperhidrosis during the night | 516 (29.7) | 242 (28.3) | 236 (30.2) | 38 (38.0) | 0.04 | 0.016 |
| Cold intolerance | 804 (46.4) | 360 (42.2) | 395 (50.7) | 49 (49.0) | 0.003 | 0.006 |
| Heat intolerance | 487 (28.0) | 244 (28.6) | 204 (26.1) | 39 (39.0) | 0.059 | 0.33 |
| Pupillomotor domain | ||||||
| Oversensitive to bright light | 485 (28.0) | 226 (26.5) | 229 (29.2) | 30 (30.3) | 0.57 | 0.40 |
| Sexual domain | 711 (63.0) | 365 (61.9) | 315 (63.6) | 31 (72.1) | 0.76 | 0.73 |
| Men: erection problem | 513 (56.1) | 238 (51.5) | 254 (60.3) | 21 (65.6) | 0.21 | 0.085 |
| Men: ejaculation problem | 393 (45.9) | 181 (41.6) | 197 (50.4) | 15 (50.0) | 0.14 | 0.099 |
| Women: vaginal lubrication | 144 (48.5) | 88 (53.0) | 48 (41.4) | 8 (53.3) | 0.081 | 0.12 |
| Women: problem with orgasm | 166 (57.4) | 99 (61.9) | 59 (51.3) | 8 (57.1) | 0.17 | 0.12 |
Eight cases with missing H&Y status are not shown.
a
Adjusted for age, sex, and disease duration (except gender‐specific sexual domain not adjusted for sex).