Table 6.

Discriminative validity of the MDS‐NB measures in the detection of PD‐MCI including optimal diagnostics cutoffs, sensitivity, specificity, and positive predictive value and negative predictive value

	PD‐MCI Classification > DRS‐II Cutoff = –2.0 SDs										PD‐MCI Classification > DRS‐II Cutoff = –1.5 SDs
	HC (n = 120) vs. PD‐MCI (n = 23)					PD‐ND (n = 83) vs. PD‐MCI (n = 23)					HC (n = 120) vs. PD‐MCI (n = 35)					PD‐ND (n = 71) vs. PD‐MCI (n = 35)
	Cutoff	Se	Sp	PPV	NPV	Cutoff	Se	Sp	PPV	NPV	Cutoff	Se	Sp	PPV	NPV	Cutoff	Se	Sp	PPV	NPV
1. Attention and WM
TMT‐A	42/43	0.87	0.70	0.74	0.84	42/43	0.87	0.52	0.64	0.80	46/47	0.66	0.82	0.79	0.71	39/40	0.83	0.50	0.62	0.75
DS backward	5/6	0.78	0.83	0.82	0.79	6/7	0.96	0.43	0.63	0.91	5/6	0.77	0.83	0.82	0.78	5/6	0.77	0.66	0.69	0.74
2. Executive function
TMT‐B	116/117	0.87	0.85	0.85	0.87	116/117	0.87	0.65	0.71	0.83	100/101	0.91	0.75	0.78	0.89	103/104	0.89	0.59	0.68	0.84
PST‐C	41/42	0.48	0.98	0.96	0.65	40/41	0.48	0.89	0.81	0.63	38/39	0.49	0.93	0.88	0.65	38/39	0.49	0.90	0.83	0.64
3. Language
Semantic fluency	51/52	0.87	0.93	0.93	0.88	52/53	0.87	0.87	0.87	0.87	64/65	0.94	0.57	0.69	0.90	57/58	0.77	0.80	0.79	0.78
WAIS‐R Sim	18/19	0.61	0.89	0.85	0.70	21/22	0.74	0.77	0.76	0.75	22/23	0.74	0.61	0.65	0.70	22/23	0.74	0.69	0.70	0.73
4. Memory
RAVLT‐DR	6/7	0.78	0.80	0.80	0.78	6/7	0.78	0.79	0.79	0.78	6/7	0.60	0.80	0.75	0.67	6/7	0.60	0.80	0.75	0.67
WMS‐III FP‐DR	23/24	0.70	0.83	0.80	0.73	27/28	0.78	0.62	0.67	0.74	26/27	0.60	0.79	0.74	0.66	27/28	0.66	0.63	0.64	0.65
5. Visuospatial functions
JoL	23/24	0.59	0.81	0.76	0.66	21/22	0.47	0.79	0.69	0.60	23/24	0.63	0.81	0.77	0.69	22/23	0.59	0.78	0.73	0.66
CLOX I	11/12	0.81	0.98	0.98	0.84	11/12	0.81	0.39	0.57	0.67	12/13	0.84	0.92	0.91	0.85	13/14	0.91	0.26	0.55	0.74

Cutoff = optimal diagnostic cutoffs (cutoffs with maximum combined sensitivity and specificity). 2. Executive function = Letter fluency (N + K + P).

Se, sensitivity; Sp, specificity; PPV, positive predictive value; NPV, negative predictive value; PST‐C, Prague Stroop Test Interference Score; Semantic fluency (animals + clothes + shopping); WAIS‐R Sim, Similarities; RAVLT‐DR, Rey Auditory Verbal Learning Test Delayed Recall; WMS‐III FP‐DR, Wechsler Memory Scale, Third Revision Family Pictures Delayed Recall; JoL, Judgment of Line Orientation; CLOX‐I Royall's CLOX.