Table 1.
Two-point LOD scores used in the Fine-mapping of the locus associated with autosomal dominant AI in family AMI1
| Marker | Genetic positiona | Physical positionb | 0 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 0.01 | 0.02 | 0.03 | 0.04 | 0.05 | 0.1 | 0.2 | 0.3 | |||
| D8S1783 | 154.71 | 137,339,899 | −0.58 | 0.92 | 1.46 | 1.75 | 1.95 | 2.08 | 2.36 | 2.21 | 1.68 |
| D8S274 | 155.94 | 137,687,609 | −4.66 | 0.61 | 1.14 | 1.42 | 1.6 | 1.73 | 1.97 | 1.81 | 1.34 |
| D8S523 | 156.5 | 138,217,023 | −2.47 | 0.09 | 0.37 | 0.53 | 0.64 | 0.72 | 0.9 | 0.89 | 0.69 |
| D8S1050 | 160.14 | 139,724,989 | −3.35 | 2.26 | 2.77 | 3.03 | 3.18 | 3.28 | 3.39 | 2.95 | 2.18 |
| D8S1024 | 165.78 | 141,497,876 | −0.86 | 1.62 | 1.86 | 1.98 | 2.04 | 2.08 | 2.06 | 1.7 | 1.19 |
| D8S1744 | 168.86 | 143,101,135 | −1.36 | 0.76 | 1.02 | 1.15 | 1.24 | 1.29 | 1.37 | 1.2 | 0.87 |
| VNTRI | 169.09 | 143,214,611 | 1.54 | 4.24 | 4.44 | 4.51 | 4.54 | 4.53 | 4.31 | 3.5 | 2.48 |
| D8S161 | 169.57 | 143,444,873 | 5.07 | 4.99 | 4.92 | 4.84 | 4.76 | 4.68 | 4.27 | 3.39 | 2.4 |
| VNTR6 | 170.69 | 143,988,705 | 1.36 | 4.04 | 4.25 | 4.33 | 4.36 | 4.36 | 4.17 | 3.42 | 2.45 |
| D8S373 | 171.32 | 144,296,507 | 4.58 | 4.5 | 4.43 | 4.36 | 4.29 | 4.21 | 3.83 | 3 | 2.06 |
| D8S2334 | 171.32 | 146,101,309 | 6.27 | 6.18 | 6.08 | 5.99 | 5.89 | 5.79 | 5.29 | 4.2 | 2.98 |
| D8S1926 | 172.62 | 146,114,938 | 2.82 | 2.77 | 2.72 | 2.67 | 2.62 | 2.57 | 2.31 | 1.77 | 1.17 |
The marker name shown in bold was present within the genome-wide linkage panel. A maximum two-point LOD score of 6.3 and a maximum multipoint LOD score of 7.5 were obtained at marker D8S2334 (highlighted in italics)
a
Sex-averaged Kosambi map distance (cM) from the Rutgers map (Kong et al. 2004)
b
Sequence-based physical map distance in bases according to Build 35 of the human reference sequence (International Human Genome Sequence Consortium 2004)