Table 2.
Differential expression data for the mouse orthologues of the Five genes (Amelx, Enam, Mmp20, Klk4, and Dlx3), mutations within which are known to cause AI, and 56 human genes from the ADAI candidate region that have a known orthologue in mouse
| Gene ID | Gene name | Log2 (Diff.) | P value | LOD score |
|---|---|---|---|---|
| AMELX | Amelogenin X chromosome | 7.603 | 5.15 × 10−20 | 40.663 |
| ENAM | Enamelin | 7.435 | 4.57 × 10−18 | 37.317 |
| KLK4 | Kallikrein | 5.293 | 9.37 × 10−17 | 34.780 |
| DLX3 | Distal-less homeobox 3 | 3.388 | 3.44 × 10−10 | 19.587 |
| CYP11B2 | Cytochrome P450, family 11, subfamily b, member 2 | −0.346 | 0.131 | −4.824 |
| LY6E | Lymphocyte antigen 6 complex, locus E | −0.973 | 0.030 | −2.823 |
| LY6H | Lymphocyte antigen 6 complex, locus H | 1.836 | 0.040 | −3.239 |
| LOC338328 | High density lipoprotein-binding protein | −0.332 | 0.754 | −7.093 |
| ZFP41 | Zinc finger protein 41 homolog (mouse) | −0.192 | 0.060 | −5.373 |
| GL14 | GLI-kruppel family member GL14 | −0.375 | 0.310 | −5.991 |
| TOP1MT | Topoisomerase (DNA) I, mitochondrial | −0.439 | 0.411 | −6.366 |
| RHPN1 | Rhophilin, Rho GTPase binding protein 1 | −0.163 | 0.747 | −7.084 |
| ZC3HDC3 | Zinc finger CCCH type domain containing 3 | 0.246 | 0.224 | −5.552 |
| GSDMDC1 | Gasedermin domain containing 1 | 0.163 | 0.524 | −6.674 |
| NAPRT1 | Nicotinate phosphoribosyltransferase domain containing 1 | −1.042 | 0.034 | −4.856 |
| EEF1D | Eukaryotic translation elongation factor 1 delta | −0.109 | 0.743 | −7.078 |
| TIGD5 | Tigger transposable element derived 5 | 0.674 | 1.15 × 10−4 | 4.314 |
| PYCRL | Pyrroline-5-carboxylate reductase-like | −0.066 | 0.883 | −7.220 |
| TSTA3 | Tissue specific transplantation antigen P35B | −0.350 | 0.519 | −6.662 |
| ZNF623 | Zinc finger protein 623 | −0.056 | 0.794 | −7.226 |
| ZNF707 | Zinc finger protein 707 | 0.065 | 0.798 | −7.227 |
| ERK8 | Extracellular singal-regulated kinase 8 | 0.060 | 0.853 | −7.198 |
| FLJ46072 | FLJ46072 protein | 0.810 | 0.336 | −6.097 |
| SCRIB | Scribbled homolog (Drosophila) | 0.074 | 0.897 | −7.229 |
| SIAHBP1 | Fuse-binding protein-interacting repressor | −0.151 | 0.650 | −6.934 |
| NRBP2 | Nuclear receptor binding protein 2 | 0.569 | 0.366 | −6.824 |
| EPPK1 | Epiplakin 1 | 0.171 | 0.876 | −7.215 |
| PLEC1 | Plectin 1, intermediate filament binding protein 500 kDa | −2.099 | 0.002 | 0.816 |
| GRINA | Glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 | −1.571 | 0.009 | −1.210 |
| SPATC1 | Spermatogensesis and centirole associated 1 | 0.124 | 0.821 | −7.235 |
| OPLAH | 5-oxoprolinase(ATP-hydrolysing) | 0.657 | 0.002 | 0.460 |
| EXOSC4 | Exosome component 4 | −0.250 | 0.328 | −6.065 |
| GPAA1 | GPAA1P anchor attachment protein 1 homolog (yeast) | 1.234 | 3.35 × 105 | 5.808 |
| CYC1 | Cytochrome c-1 | −0.775 | 0.084 | −4.220 |
| SHARPIN | Shank-interacting protein-like 1 alpha | −0.436 | 0.092 | −4.348 |
| MAF1 | Homolog of yeast MAF 1 | −0.404 | 0.376 | −6.246 |
| BOP1 | Block of proliferation 1 | −0.472 | 0.210 | −5.463 |
| HSF1 | Heat shock transcription factor 1 | −0.396 | 0.307 | −5.977 |
| DGAT1 | Diacylglycercol O-acyltransferase homolog 1 (mouse) | −0.574 | 0.349 | −6.149 |
| SCRT1 | Scratch homolog 1, zinc finger protein (Drosophila) | −0.330 | 0.539 | −6.711 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | −0.100 | 0.840 | −7.188 |
| GPR172A | G protein-coupled receptor 172A | 0.362 | 0.223 | −5.542 |
| ADCK5 | aarF domain containing kinase 5 | −0.699 | 0.123 | −4.731 |
| CPSF1 | Cleavage and polyadenylation specific factor 1, 160 kDa | −0.740 | 0.004 | −0.148 |
| SLC39A4 | Solute carrier family 39 (zinc transporter), member 4 | -0.186 | 0.889 | |
| VPS28 | Vacuolar protein sorting 28 (yeast) | −0.455 | 0.057 | |
| NFKBIL2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 | −0.197 | 0.680 | −6.985 |
| CYHR1 | Cysteine and histidine rich 1 | 0.980 | 3.06 × 10−4 | 3.081 |
| KIFC2 | Kinesin family member c2 | 0.242 | 0.374 | −6.242 |
| FOXH1 | Forkhead box H1 | 0.849 | 0.001 | −1.658 |
| PPP1R16A | Protein phosphatase 1, regulatory (inhibitor) subunit 16A | −0.356 | 0.243 | −5.657 |
| GPT | Glutamuic-pyruvate transaminase (alanine aminotransferase) | −0.753 | 0.012 | −1.566 |
| MFSD3 | Major facilitator superfamily domain containing 3 | −0.278 | 0.364 | −6.820 |
| RECQL4 | RecQ protein-like 4 | −0.183 | 0.673 | −6.974 |
| LRRC14 | Leucine rich repeat containing 14 | 0.516 | 0.094 | −4.380 |
| LRRC24 | Leucine rich repeat containing 24 | −0.310 | 0.453 | −6.960 |
| ZNF251 | Zinc finger protein 251 | 0.373 | 0.279 | −5.848 |
| RPL8 | Ribosomal protein L8 | −0.165 | 0.714 | −7.037 |
| ZNF7 | Zinc Wnger protein 7 (KOX 4, clone HF.16) | −0.582 | 0.387 | −6.287 |
| COMMD5 | COMM domain containing 5 | −0.439 | 0.020 | −2.288 |
| ZNF647 | Zinc Wnger protein 647 | 0.342 | 0.453 | −6.487 |
| ZNF16 | Zinc Wnger protein 16 (KOX 9) | −0.375 | 0.310 | −5.991 |
Seven hypothetical genes identified a putative mouse orthologue present on the MGE 430 2.0 array, but were omitted from this table. Of the 29 genes not present on the MGE 430 2.0 array, only four have a known murine orthologue, the remaining 25 are all hypothetical. Log-odds of differential expression were calculated by empirical Bayes shrinkage of the gene-wise sample variances towards a common value (Smyth 2004)
P-values less than 0.05 are highlighted in bold
Seven of the ten genes that were sequenced and present on the MGE430 2.0 microarray are highlighted in italics