Fig. 3.

MDL28170 inhibited calpain activity in lung tissue and ameliorated lung damage in the first hour after burn injury. a Grouped results of calpain activity. b Representative hematoxylin and eosin staining of lung tissue (magnification, × 200). c–e Grouped results of histology score, wet to dry weight ratios, and caspase-3 activity, respectively. Each bar represents the mean ± SEM; n = 6 rats. ^##P < 0.01 vs sham. *P < 0.05, **P < 0.01 vs B-1 h. B-1 h, the samples were obtained at the first hour after scald burn. D1 and D3 stand for MDL28170 at a dose of 1 and 3 mg/kg b. w., respectively. MDL28170 was given intravenously 1 h before burn injury. AMC 7-amido-4-methylcoumarin