Table 2.

Association of p16 expression and OS by histotype

Histotype	Expression	N	HR (95% CI)	P value
High‐grade serous	Heterogeneous	1550	ref	0.68
	Absent	244	1.06 (0.90–1.25)
	Block	2292	1.03 (0.95–1.11)
Low‐grade serous	Heterogeneous	166	ref	0.001
	Absent	25	2.95 (1.61–5.38)
	Block	13	1.54 (0.72–3.29)
Clear cell	Heterogeneous	463	ref	<0.001
	Absent	138	0.67 (0.47–0.96)
	Block	92	2.02 (1.47–2.77)
Endometrioid	Heterogeneous	650	ref	0.004
	Absent	117	0.98 (0.66–1.45)
	Block	73	1.88 (1.30–2.75)
Mucinous	Heterogeneous	163	ref	0.80
	Absent	187	1.05 (0.72–1.55)
	Block	21	1.28 (0.61–2.64)

Adjusted for study, age, time interval, stage and residual tumor; ref, reference.

Smaller sample size is due to availability of age and time interval information.