Table 2.

Characteristics of the 4 Patients in Whom FRP Occurred Within 2 Months After the Start of SBRT and Resulted in Death in 1 Month.

Case No.	Duration From SBRT to Onset of FRP, days	Duration From Onset of FRP to Death, days	Age (years)	Sex	Tumor Size (mm)	Brinkman Index	Pulmonary Interstitial Change Before SBRT	Administration of Steroid Before SBRT	Chronis Cardiac Disease	KL-6	%VC	FEV 1.0%	SBRT Dose (Gy/fraction)	V20 (Lung-GV)	MLD, Gy
2	42	4	64	Female	30	Unknown	Negative	Positive	Positive	NA	60%	83.0%	75/10	20.5%	3.0
14	44	19	72	Male	15	300	Negative	Positive	Negative	835	79%	68.9%	48/4	6.3%	4.9
16	56	15	85	Male	38	800	Positive	Negative	Positive	989	103%	71.8%	48/4	6.3%	4.3
20	42	30	63	Male	30	840	Negative	Negative	Positive	NA	65%	73.7%	60/8	18.2%	9.8

Abbreviation: FEV1.0%: forced expiratory volume percent in one second; FRP, fatal radiation pneumonitis; KL-6, Krebs von den Lungen-6; MLD: mean dose of normal lung; NA: not assigned; SBRT, stereotactic body radiation therapy; %VC: percent vital capacity; V20, ratio of the volume receiving 20Gy or more to the normal lung volume.