Table 3.

Frequency of Radiation Pneumonitis Post-SBRT for Lung Cancer According to Presence of Pulmonary Interstitial Change.

Pulmonary Interstitial Change	Author (Ref)	Study Design	Patient Number	Dose/Fraction	Grade of Radiation Pneumonitis	Frequency	Risk Factor
No pulmonary interstitial change	Matsuo et al 7	Retrospective	74	48 Gy/4 fr	3	10.6%	V25
					4	1.9%
	Nagata et al 11	Prospective	104 (inoperable)	48 Gy/4 fr	3	6.2%
			65 (operable)	48 Gy/4 fr	3	3.6%
	Yamaguchi et al 12	Retrospective	86	48 Gy/4 fr	4-5	0.0%
	Ueki et al 13	Retrospective	137	48-60 Gy/4-8 fr	3-5	1.4%
	Yoshitake et al 14	Retrospective	242	48 Gy/4 fr	3	1.2%
					4-5	0.0%
With pulmonaryinterstitial change	Yamaguchi et al 12	Retrospective	16	48 Gy/4 fr	3	6.3%	V5-25, MLD
					4	6.3%
					5	6.3%
	Ueki et al 13	Retrospective	20	40-60Gy/4-8 fr	3-5	10.0%
	Yoshitake et al 14	Retrospective	18	48 Gy/4 fr	3	16.7%	KL-6, V5, V10, MLD
					4-5	22.3%

Abbreviations: KL-6, Krebs von den Lungen-6; MLD, mean dose of normal lung; SBRT, stereotactic body radiation therapy