FIG. 3.

A clue to Gadd45 function by use of an informatics approach. (A) Six of 16 lines with functional p53 were found to show deficient γ-ray induction of GADD45 in the NCI screen. (B) Wilcoxon rank sum test was used to determine whether individual compounds tested were more active in cell lines with competent GADD45 induction (p-value = 1) or more active in cell lines with deficient GADD45 induction (p-value = 0); results are shown for a selection of COMPARE-identified topoisomerase II inhibitors (8). (C) Results for the remainder of the database of tested compounds.