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Schematic diagram of plasmids and encoded chimeric mRNAs. mRNAs are transcribed from the adenovirus major late promoter (Ad MLP), express the hepatitis B virus S-antigen open reading frame (S-Ag ORF), and contain a 3′ noncoding region (3′NCR) with either the GM-CSF AU-rich sequence (AUUUA)5 or a control sequence (AUUGC)5.
