Table 5.
Frequency of placental maternal and fetal vascular malperfusion lesions of normal singleton pregnant women at term.
| Histologic Lesionsa | % (n/N) |
|---|---|
| Maternal vascular malperfusion | 35.6% (337/946) |
| A. Villous Changes | 18.6% (176/946) |
| Villous infarct(s) | 5.6% (53/945) |
| Increased syncytial knots | 8.5% (80/946) |
| Villous agglutination | 2.0% (19/946) |
| Increased intervillous fibrin deposition | 6.3% (60/946) |
| Distal villous hypoplasia | 0.1% (1/946) |
| B. Vascular Lesions | 20.5% (194/946) |
| Persistent muscularization of basal plate arteries | 16.3% (154/946) |
| Mural hypertrophy of decidual arterioles | 1.8% (17/946) |
| Acute atherosis of basal plate arteries and/or decidual arterioles | 0.8% (8/946) |
| Spiral artery fibrinoid necrosis | 0.3% (3/944) |
| Decidual vascular thrombosis | 1.7% (16/944) |
| Persistence of endovascular trophoblast | 0.3% (3/944) |
| Retroplacental hemorrhage | 0.8% (8/944) |
| ≥ 2 lesions of maternal vascular malperfusion | 7.4% (70/946) |
| ≥ 3 lesions of maternal vascular malperfusion | 1.2% (11/946) |
| Fetal vascular malperfusion | 19.7% (186/946) |
| A. Villous Changes | 11.3% (107/946) |
| Early | |
| Villous stromal-vascular karyorrhexis | 2.5% (24/946) |
| Late | |
| Hyalinized avascular villi, small foci | 6.6% (62/946) |
| Hyalinized avascular villi, variable sized foci | 2.0% (19/946) |
| Severe | |
| Fetal thrombotic vasculopathy | 0.2% (2/946) |
| B. Vascular Lesions | 9% (85/946) |
| Thrombi in large fetal vessels | 2.6% (25/946) |
| Intimal fibrin deposition, large fetal vessels | 6.4% (61/946) |
| Fibromuscular sclerosis, intermediate-sized fetal vessels | 0% (0/946) |
| ≥ 2 lesions of fetal vascular malperfusion | 0.7% (7/946) |
a
Placentas may have more than one type of maternal and fetal vascular malperfusion lesions.