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. Author manuscript; available in PMC: 2018 Oct 8.
Published in final edited form as: ACS Chem Biol. 2017 Jun 28;12(8):2062–2069. doi: 10.1021/acschembio.7b00480

Figure 1.

Figure 1.

(A) aAA biosynthesized from aLA. Elongation products of aLA to aAA were measured in aLA-incorporated RAW264.7 macrophages. Quantities of each intermediate are the mean ± standard deviation of triplicate analyses. (B) KLA activation induces lipid electrophile protein adduction. Lipid electrophiles are generated during normal physiological processes of the cell (+aLA/-KLA), and increased adduction is measured across the proteome by endogenously formed lipid electrophiles in activated macrophages (+aLA/+KLA).