Table 3.
STZ-induced mortality appears to depend on the age of the rat at the time of STZ injection.
| Body weight (g) | 220–400 | 220–400 | 401–500 | 501–600 | 501–600 | Total |
|---|---|---|---|---|---|---|
| Age (weeks) | 6–11 | 6–11 | 12–17 | 18–23 | 18–23 | |
| Rats received single STZ 65 mg/kg i.v. | 50 | 0 | 29 | 20 | 0 | 99 |
| Rats received single STZ 50 mg/kg i.v. | 0 | 0 | 0 | 0 | 14 | 14 |
| Rats received double STZ 50 mg/kg i.v. 3 days apart | 0 | 17 | 0 | 0 | 0 | 17 |
| Total rats injected with STZ | 50 | 17 | 29 | 20 | 14 | 130 |
| Rats surviving the 1st week after STZ i.v. | 48 | 17 | 5 | 3 | 0 | 73 |
| % surviving the 1st week post injection | 96% | 100% | 17.2% | 8.8% | 0% | — |
| Week of mortality after the 1st week | — | — | 9, 12, 21, 21, 25 | 9, 9, 21 | — | — |
| % surviving to end of study at week 60 | 96% | 100% | 0% | 0% | 0% | — |