Table 4.
Time course of urinary protein excretion (g per 24 h) in individual patients with RMN from entry into the study (baseline) to end of study (month 12).
| Patient no. | Primary IST | Indication | Baseline | Month 3 | Month 6 | Month 12 | Baseline to month 12 a | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Urinary protein excretion | Serum albumin | urinary protein excretion | Serum albumin | urinary protein excretion | Serum albumin | urinary protein excretion | Serum albumin | urinary protein excretion | Serum albumin | |||
| 1 | cCTX/GC | Resistant | 4.40 | 27.90 | 6.31 | 20.20 | 6.18 | 20.20 | 3.59 | 35.20 | -0.81 | 7.30 |
| 2 | CsA/GC | Intolerant | 5.60 | 22.50 | 2.80 | 26.70 | 5.70 | 18.00 | 3.75 | 18.80 | -1.85 | -3.70 |
| 3 | CsA/GC | Relapse | 4.47 | 24.20 | 2.82 | 37.90 | 1.60 | 40.00 | 1.13 | 41.00 | -3.34 | 16.80 |
| 4 | cCTX/GC | Resistant | 4.00 | 25.30 | 2.65 | 37.50 | 0.56 | 46.10 | 1.28 | 47.00 | -2.72 | 21.70 |
| 5 | cCTX/GC | Resistant | 7.28 | 22.10 | 5.07 | 24.66 | 2.87 | 32.89 | 1.33 | 45.00 | -5.95 | 22.90 |
| 6 | TAC | Intolerant | 4.80 | 23.70 | 3.08 | 29.30 | 1.16 | 44.60 | 1.60 | 44.32 | -3.20 | 20.62 |
| 7 | TAC | Intolerant | 5.72 | 25.92 | 3.18 | 34.54 | 3.78 | 34.97 | 2.78 | 40.00 | -2.94 | 14.08 |
| 8 | CsA/GC | Relapse | 10.00 | 19.00 | 6.92 | 25.40 | 3.34 | 28.10 | 2.11 | 38.60 | -7.89 | 19.60 |
| 9 | cCTX/GC | Resistant | 6.17 | 24.00 | 4.58 | 30.40 | 1.63 | 46.60 | 0.17 | 47.36 | -6.00 | 23.36 |
| 10 | CsA/GC | Relapse | 3.10 | 27.10 | 1.45 | 43.00 | 0.23 | 49.00 | 0.21 | 49.00 | -2.89 | 21.90 |
| 11 | CsA/GC | Relapse | 5.10 | 24.50 | 2.00 | 44.50 | 1.80 | 41.40 | 1.13 | 45.00 | -3.97 | 20.50 |
| 12 | cCTX/GC | Resistant | 6.08 | 26.30 | 3.44 | 30.60 | 3.25 | 39.40 | 1.78 | 42.00 | -4.30 | 15.70 |
| 13 | CsA/GC | Resistant | 5.08 | 24.20 | 2.47 | 41.80 | 1.58 | 39.70 | 2.45 | 39.70 | -2.63 | 15.50 |
| 14 | cCTX/GC | Relapse | 4.20 | 23.70 | 6.80 | 14.80 | 6.20 | 14.50 | 3.30 | 21.80 | -0.90 | -1.90 |
| 15 | CsA/GC | Resistant | 13.00 | 15.80 | 5.53 | 15.40 | 5.20 | 18.00 | 3.32 | 29.63 | -9.68 | 13.83 |
| Mean | / | / | 5.93 | 23.88 | 3.94 | 30.45 | 3.01 | 34.23 | 1.99 | 38.96 | -3.94 | 15.21 |
| SD | / | / | 2.54 | 3.28 | 1.78 | 9.47 | 2.02 | 11.69 | 1.17 | 9.08 | 2.48 | 8.48 |
| Median | / | / | 5.10 | 24.20 | 3.17 | 30.40 | 2.86 | 39.40 | 1.78 | 41.00 | -3.20 | 16.80 |
Abbreviations. RMN: refectory membranous nephropathy; IST: immunosuppressive therapy; cCTX/GC: cyclical cyclophosphamide and steroids; TAC: tacrolimus; CsA/GC: cyclosporin and steroids.
aPaired t-test P<0.001 for 12-month change.