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Bone marrow biopsy. (a) Staining with hematoxylin and eosin shows a population of abnormal plasma cells, many with binucleate and multinucleate forms. (b) Staining for CD138, a plasma marker, shows strong and diffuse positivity. (c) Fluorescence in situ hybridization (FISH) shows a monoclonal population with lambda light chain restriction, as essentially all cells are positive for lambda light chain and negative for kappa light chain.
