Table 3.
Hcy-keratin and S-Hcy-keratin levels and the solubility of hair Hcy-keratin in HHcy and control wild-type mice.
| Genotype (n) | Hcy-keratin (pmol/mg hair) | S-Hcy-keratin (pmol/mg hair) | Hcy-keratin/(Hcy-keratin + S-Hcy-keratin) | SDS-soluble Hcy-keratin fraction |
|---|---|---|---|---|
| Cbs −/− (4) | 1014 ± 86∗ | 1937 ± 336∗ | 0.35 ± 0.03 | 0.07 ± 0.03∗ |
| Cse −/− (5) | 546 ± 46∗ | 682 ± 144∗ | 0.55 ± 0.04 | 0.14 ± 0.01∗ |
| Mthfr −/− (7) | 302 ± 71# | 248 ± 121# | 0.57 ± 0.17 | 0.19 ± 0.03# |
| Wild type + Met (6) | 97 ± 11 | 303 ± 58∗ | 0.24 ± 0.02 | 0.31 ± 0.07 |
| Wild type (28) | 87 ± 10 | 127 ± 10 | 0.41 ± 0.21 | 0.36 ± 0.09 |
∗,#Significantly different from wild type; ∗P < 0.001,#P < 0.05.