Summary of 74 double-positive cases in the published articles. ANCA, antineutrophil cytoplasmic antibody; AZP, azathioprine; CPA, cyclophosphamide; CS, corticosteroids; DAH, diffuse alveolar hemorrhage; ESRD; end-stage renal disease; GBM, glomerular basement membrane; IS, immunosuppression; MMF, mycophenolate mofetil; MPO, myeloperoxidase; MTX, methotrexate; PE, plasma exchange; PR3, proteinase 3; RIT, rituximab; RRT, renal replacement therapy; wk, week.