Table 3.
Adjusted hazard ratios (HR) of incident cardiovascular events and mortality and the 5‐year number needed to treat to prevent one event by statins use, by patients' coronary risk
| Statin nonusers | Statin users MPR <70% | Statin users MPR ≥70% | Statin users MPR <70% | Statin users MPR ≥70% | |||||
|---|---|---|---|---|---|---|---|---|---|
| Events | Incidence (95% CI) | Events | Incidence (95% CI) | Events | Incidence (95% CI) | Adjusted HR(95% CI) | Adjusted HR(95% CI) | ||
| Outcomes of interest | 5‐year NNT | ||||||||
| <5% | |||||||||
| Composite ASCVD | 7113 | 2.04(1.76–2.31) | 153 | 3.74(3.08–4.39) | 150 | 3.58(2.94–4.21) | 0.91(0.74–1.13) | 0.74(0.52–1.04) | 470 |
| Coronary heart disease | 6136 | 1.76(1.51–2.01) | 138 | 3.37(2.73–4.01) | 149 | 3.55(2.97–4.14) | 0.90(0.73–1.12) | 0.80(0.57–1.13) | 400 |
| Ischemic stroke | 4228 | 1.21(1.05–1.37) | 88 | 2.14(1.68–2.61) | 98 | 2.32(1.81–2.82) | 0.84(0.65–1.09) | 0.75(0.51–1.11) | 838 |
| All‐cause mortality | 8604 | 2.44(2.28–2.60) | 111 | 2.67(2.10–3.24) | 125 | 2.94(2.39–3.49) | 0.85(0.66–1.08) | 0.83(0.55–1.27) | 668 |
| ≥5–7.4% | |||||||||
| Composite ASCVD | 2360 | 6.85(6.52–7.19) | 86 | 6.96(5.27–8.65) | 106 | 6.49(4.97–8.01) | 0.97(0.74–1.27) | 0.84(0.64–1.09) | 204 |
| Coronary heart disease | 2150 | 6.23(5.86–6.60) | 86 | 7.00(5.14–8.85) | 99 | 6.04(4.76–7.33) | 0.95(0.72–1.26) | 0.77(0.61–0.97) | 155 |
| Ischemic stroke | 1346 | 3.87(3.63–4.11) | 47 | 3.79(2.53–5.04) | 64 | 3.91(2.74–5.07) | 0.97(0.67–1.40) | 0.87(0.61–1.25) | 480 |
| All‐cause mortality | 2451 | 6.96(6.53–7.39) | 61 | 4.83(3.42–6.25) | 85 | 5.11(3.90–6.32) | 0.90(0.66–1.24) | 0.88(0.67–1.14) | 325 |
| ≥7.5–9.9% | |||||||||
| Composite ASCVD | 1355 | 9.99(9.30–10.68) | 63 | 9.86(6.90–12.82) | 81 | 8.43(6.44–10.41) | 0.89(0.63–1.27) | 0.70(0.54–0.92) | 75 |
| Coronary heart disease | 1148 | 8.42(7.60–9.24) | 63 | 9.78(6.85–12.71) | 78 | 8.11(6.19–10.02) | 0.93(0.66–1.30) | 0.71(0.54–0.94) | 90 |
| Ischemic stroke | 803 | 5.84(5.38–6.29) | 34 | 5.18(3.18–7.19) | 54 | 5.54(3.88–7.20) | 0.89(0.58–1.38) | 0.86(0.62–1.19) | 273 |
| All‐cause mortality | 1429 | 10.20(9.42–10.97) | 45 | 6.85(4.46–9.24) | 65 | 6.57(4.89–8.25) | 0.91(0.63–1.32) | 0.85(0.63–1.13) | 177 |
| ≥10–19.9% | |||||||||
| Composite ASCVD | 1391 | 13.34(12.57–14.1) | 105 | 14.15(11.30–17.00) | 151 | 12.04(10.08–14.01) | 0.96(0.77–1.20) | 0.74(0.61–0.90) | 62 |
| Coronary heart disease | 1241 | 11.84(11.10–12.58) | 86 | 11.61(8.96–14.26) | 142 | 11.27(9.36–13.18) | 0.83(0.64–1.07) | 0.74(0.60–0.92) | 71 |
| Ischemic stroke | 811 | 7.64(7.06–8.21) | 60 | 7.88(5.84–9.92) | 93 | 7.30(5.79–8.80) | 0.97(0.74–1.29) | 0.78(0.61–1.00) | 127 |
| All‐cause mortality | 1587 | 14.57(13.78–15.35) | 105 | 13.53(10.74–16.31) | 125 | 9.61(7.78–11.44) | 1.15(0.92–1.43) | 0.73(0.59–0.91) | 69 |
Incidence 1,000p/year. 5‐year NNT: calculated for statin users with MPR ≥70%.