Table 4.
Adjusted hazard ratios (HR) of adverse effects of statins use, by coronary risk of participants with adverse event
| Statin nonusers | Statin users MPR < 70% | Statin users MPR ≥ 70% | Statin users MPR < 70% | Statin users MPR ≥ 70% | ||||
|---|---|---|---|---|---|---|---|---|
| Events | Incidence (95% CI) | Events | Incidence (95% CI) | Events | Incidence (95% CI) | Adjusted HR (95% CI) | Adjusted HR (95%CI) | |
| <5% | ||||||||
| Cancer | 21 077 | 7.04(6.54–7.54) | 312 | 8.97(7.90–10.04) | 414 | 11.68(10.51–12.85) | 0.91(0.80–1.03) | 1.06(0.87–1.30) |
| Type 2 diabetes | 20 922 | 7.18(6.45–7.92) | 394 | 12.23(10.96–13.50) | 515 | 16.29(14.77–17.80) | 0.99(0.86–1.14) | 1.15(0.91–1.46) |
| Hemorrhagic stroke | 1451 | 0.48(0.43–0.53) | 30 | 0.84(0.52–1.16) | 25 | 0.68(0.40–0.95) | 1.10(0.73–1.65) | 0.77(0.46–1.29) |
| Acute liver disease | 263 | 0.57(0.48–0.65) | 9 | — | 2 | — | — | — |
| Myopathy | 44 | 0.09(0.07–0.12) | 3 | — | 3 | — | — | — |
| ≥5–7.4% | ||||||||
| Cancer | 4306 | 14.68(14.12–15.25) | 124 | 11.80(9.18–14.42) | 188 | 13.53(11.41–15.65) | 0.94(0.75–1.18) | 1.02(0.85–1.22) |
| Type 2 diabetes | 4549 | 18.35(17.72–18.99) | 170 | 21.29(17.45–25.12) | 258 | 26.87(23.19–30.54) | 1.12(0.91–1.37) | 1.32(1.12–1.56) |
| Hemorrhagic stroke | 396 | 1.30(1.16–1.44) | 12 | 1.11(0.37–1.85) | 14 | 1.00(0.38–1.62) | 0.92(0.45–1.85) | 0.74(0.39–1.41) |
| Acute liver disease | 48 | 1.02(0.64–1.40) | 2 | — | 2 | — | — | — |
| Myopathy | 8 | — | 1 | — | 1 | — | — | — |
| ≥7.5–9.9% | ||||||||
| Cancer | 2247 | 19.50(18.50–20.49) | 90 | 16.56(12.27–20.84) | 128 | 15.55(12.70–18.39) | 1.01(0.79–1.30) | 0.92(0.74–1.13) |
| Type 2 diabetes | 1939 | 22.15(21.05–23.26) | 97 | 27.28(20.88–33.68) | 142 | 29.38(23.47–35.28) | 1.19(0.92–1.54) | 1.20(0.96–1.49) |
| Hemorrhagic stroke | 221 | 1.83(1.57–2.09) | 11 | 1.93(0.64–3.22) | 18 | 2.10(0.95–3.26) | 1.16(0.57–2.34) | 1.16(0.62–2.15) |
| Acute liver disease | 26 | 1.36(0.72–2.01) | 3 | — | 1 | — | — | — |
| Myopathy | 4 | — | 3 | — | 1 | — | — | — |
| ≥10–19.9% | ||||||||
| Cancer | 2151 | 24.33(22.99–25.67) | 136 | 21.46(17.58–25.33) | 228 | 21.38(18.43–24.34) | 1.06(0.87–1.30) | 1.00(0.85–1.18) |
| Type 2 diabetes | 1490 | 25.80(24.24–27.35) | 101 | 29.38(23.03–35.73) | 172 | 34.77(29.20–40.35) | 1.15(0.90–1.47) | 1.26(1.04–1.52) |
| Hemorrhagic stroke | 245 | 2.62(2.26–2.98) | 16 | 2.48(1.24–3.73) | 30 | 2.70(1.70–3.69) | 0.90(0.51–1.57) | 0.83(0.53–1.32) |
| Acute liver disease | 19 | 1.30(0.62–1.97) | 7 | — | 2 | — | — | — |
| Myopathy | 4 | — | 3 | — | 0 | — | — | — |
Incidence 1,000p/year.