Table 5.

Baseline covariates

Sociodemographic characteristics

Age Sex Deprivation index scorea Number of general practitioner visits in the 18 months previous to index date

Cardiovascular risk factors

High‐risk alcohol intake (ICD‐10 code: yes/no) Smoking (ICD‐10 code: yes/no) Diabetes (yes/no) or record of antidiabetic drug use Hypertension (yes/no) or record of antihypertensive drug use Dyslipidemia (ICD‐10 code: yes/no) Obesity (yes/no), defined as BMI>30 kg/m2

Measurements

Systolic blood pressure (mmHg) Diastolic blood pressure (mmHg) BMI (kg/m2) Laboratory tests: fasting glucose, total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, triglycerides.

Record of other drug use

Psychoanaleptics, psycholeptics, antiinflammatory drugs.

Other comorbidities (ICD‐10 codes: yes/no)

Chronic kidney disease, atrial fibrillation, chronic obstructive pulmonary disease, arthritis, benign neoplasms, hypo‐ and hyperthyroidism.

ICD‐10, International Classification of Disease, 10^th revision; BMI, body mass index.

^aThe study used the deprivation index derived from the multicenter MEDEA study in Spain. The index is described in detail in the Supplementary file.