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. 2018 Sep 3;126(Suppl Suppl 1):49–66. doi: 10.1111/eos.12538

Figure 2.

Figure 2

Organization of the human papillomavirus (HPV) genome. Early genes (E1, E2, E4, E5, E6, and E7) code for non‐structural proteins, while late genes (L1 and L2) code for structural proteins. The long control region (LCR) contains a DNA replication origin and several binding sites for viral and host proteins to regulate viral DNA replication. The two major promoters P97 and P670 are marked. HPV can integrate into the host cell chromosome in a random pattern. During this integration, the double‐stranded circular DNA opens, which will disturb the function of the E2 gene, as given in the lower graph. Reprinted from Rautava J and Syrjänen S. Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis. Head Neck Pathol. 2012; 6(Suppl 1): 3–1. With permission from Springer Nature via Copyright Clearance Center's RightsLink service.