Table 3.
Sample | F+ | P+ | O+ | C+ | F− | P− | O− | C− |
---|---|---|---|---|---|---|---|---|
Cumulative SR conjugates excreted in 24 h urine [μmol ± SD] | 1.51 ± 0.17 | 1.88 ± 0.38 | 1.95 ± 0.52 | 2.06 ± 0.36 | 1.2 ± 0.54 | 1.14 ± 0.50 | 0.82 ± 0.26 | 0.66 ± 0.2 |
SR bioavailability (%) calculated as cumulative SR/GR μmol in before incorporation in the gels | n.a. | n.a. | n.a. | n.a. | 11.5 ± 5.2 | 11.0 ± 4.9 | 7.9 ± 2.5 | 6.3 ± 2.0 |
SR bioavailability (%) calculated as cumulative SR/SR μmol in before incorporation in the gels | 29.4 ± 3.3 | 36.3 ± 7.4 | 37.6 ± 10.1 | 39.7 ± 7.0 | n.a. | n.a. | n.a. | n.a. |
Peak time (t max, h ± SD) for SR conjugate excretion | 1.48 ± 0.51 | 1.17 ± 0.32 | 1.82 ± 0.46 | 1.66 ± 0.46 | 7.55 ± 1.62 | 9.32 ± 3.66 | 9.26 ± 3.69 | 8.07 ± 2.75 |
n.a., not applicable.
Different letters within each row of the cumulative IB conjugate values for the samples (for each set of sample (−) and (+)) indicate significant differences (p < 0.05). The absence of letters indicates no significant difference.