Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 11;72(9):633–653. doi: 10.1111/pcn.12683

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

PMC Copyright notice

Dematuration of parvalbumin (PV)/perineuronal nets (PNN) interneurons. PNN surround synaptic boutons on neuronal soma and proximal dendrites and consist of chondroitin sulfate proteoglycans (CSPG) assembled on the hyaluronan scaffold of PV interneurons. The development of PNN is controlled by synaptic activity and their formation terminates the critical period of synaptic plasticity, consolidating the neuronal network. CSPG has a unique geometric structure of polygonal mesh shapes with the number of vertices varying from three to nine. Sizes of the mesh vary.151 A reduction in PV (green) and PNN (blue) expression is associated with a plastic and immature network observed in iPlasticity by chronic SSRI treatment.