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The methylome of the formed xenograft tumours is stable. (A) Hierarchical clustering of methylation β-values for 27 500 CpG sites, with standard deviation across samples above 0.25, groups the three samples (T – tumour, C – cell line and X – xenograft) from the same origin together for all cases. (B) Percentage of probes that change methylation status, defined as a difference in β-values >0.51 between xenograft and tumour (T) and cell line (C), respectively, was below 3% in all cases.
