Figure 3.

(A) QQ-plot; (B) Manhattan plot. The results of GWAS of human longevity using observed LLFS data on lifespan. The logistic regression model for related individuals in the GMMAT software package (11) with sex and country (DK, US) as observed covariates was used. Cases comprised individuals from the proband generation with lifespans (for deceased subjects) or censored lifespans (for living study subjects, or for those who dropped out from the study) ≥96 years (723 individuals). Controls comprised individuals from the offspring generation whose age at death (for deceased study subjects) or attained age (for study subjects with censored lifespans) <75 years (2,462 individuals).