Table 2. Studies of polymorphisms and risk of Hodgkin lymphoma.
| Reference | Place of study | Gene studied | Ethnicity | N | Cases | N | Controls |
|---|---|---|---|---|---|---|---|
| Ruiz-Cosano J et al, 2013 | Spain |
XPG.ERCC5 MTR |
Caucasian | 20 | HL a subset of lymphoma cases: no other information | 214 | Healthy blood donors matched for age, gender, ethnicity and geographical location |
| Yri O et al, 2012 | Norway |
IL10 GSTP1 GSTT1 GSTM1 UGT1A1 |
Unspecified | 224 | HL patients: 135 males, 89 males: mean age 38 (18-84). | 1056 | Healthy blood donors (age and gender unknown) |
| Ruiz-Cosano J et al, 2012 | Spain |
GSTT1 GSTM1 |
Caucasian | 20 | HL a subset of lymphoma: no other information | 214 | Healthy blood donors matched for age, gender, ethnicity and geographical location |
| Monroy C et al, 2011 | USA | COX2 | Mixed | 200 | HL patients: mean age 47.2 years (SD 13.37 years). 107 males and 93 females. 80% NSHL. | 220 | Frequency matched to the age (within 5 years), sex, and race/ethnicity of the cases. Controls randomly selected random digit dialling. Mean age 49.27 years (SD 15.19 years). 123 males and 97 females. |
| Kasperzyk J et al, 2010 | USA |
MTHFR MTR |
Mixed (predominantly Caucasian) | 497 | HL patients: mean age 38 years (SD 15 years). EBV positive 16.3% and EBV negative 57.6%. NLPHL excluded from the study. | 638 | Frequency matched to the age (within 5 year age groups), sex, and state of residency distribution of the cases. Controls randomly selected through “town books” in Boston or random digit dialling in Connecticut. |
| Ribrag V et al, 2009 | France |
GSTT1 GSTM1 GSTP1 UGT1A1 |
Unspecified | 313 | HL patients: 180 males, 133 females. Median age 32 years (range 15-93 years). | 226 | Controls obtained from the French Blood Service. |
| Lourenco G et al, 2009 | Brazil |
GSTP1 GSTT1 GSTM1 |
Mixed | 110 | HL patients: median age 27 years (range 14-82 years), 57 males 53 females. Genotype data stratified by age, gender, ethnic origin and stage of disease. | 226 | Blood donors: median age 52 years (range 25-60 years), 151 males, 75 females. |
| El-Zein R et al, 2009 | USA | XPG/ERCC5 | Mixed | 200 | HL patients: mean age 47.2 years (SD 13.37 years). 107 males and 93 females. | 220 | Frequency matched to the age (within 5 years), sex, and race/ethnicity of the cases. Controls randomly selected random digit dialling. Mean age 49.27 years (SD 15.19 years). 123 males and 97 females. |
| Chang E et al, 2009 | USA | COX2 | Mixed | 473 | HL patients: 242 males, 231 females. NLPHL excluded from the study. | 373 | Frequency matched to the age (within 5 year age groups), sex, and state of residency distribution of the cases. Controls in Boston randomly selected through “town books”. Controls in Connecticut randomly selected through digit dialling (18-65 years of age) or Medicare files (66-79 years of age). 211 males and 162 females. |
| Hoeft K et al, 2008 | Germany | COX2 | Unspecified | 116 | HL a subset of lymphoma cases. | 710 | Randomly selected from the population registers of the study region. Matched for gender, age (1 year) and study region. 390 males and 320 females. |
| Timuragaoglu A et al, 2006 | Turkey | MTHFR | Unspecified | 30 | HL a subset of lymphoma cases. | 82 | Frequency matched to cases by age and gender. |
| Deligezer A et al, 2006 | Turkey | MTHFR | Unspecified | 51 | HL a subset of lymphoma cases. 22 cases MCHL, 20 NSHL, 9 LRHL. Median age 35 years (range 19-70), 35 males, 31 females. | 154 | Frequency matched to cases by age and gender of similar ethnic background. Randomly selected. |
| Nieters A et al, 2006 | Germany | IL10 | Unspecified | 115 | HL a subset of lymphoma cases. | 710 | 1:1 matched for gender, age (within 1 year) and study region. |
| Cordano et al, 1999 | UK | IL6 | Unspecified | 584 | HL patients: 61.3% NSHL and 21.4% cHL. 33% EBV positive. | 513 | Frequency matched to cases by age and gender, region of residence. |
| Cozen W et al, 2004 | USA | IL6 | Mixed (predominantly Caucasian) | 27 | HL patients: an affected twin of a monozygotic or dizygotic pair. Geneotype data stratified by zygosity and histology. | 201 | Spouses within 5 years of the twins’ ages, non-blood relative/friend or a age (within 5 years) or ethnicity-matched control subject was chosen from employees within the institution. |
| Munro L et al, 2003 | UK | IL10 | Unspecified | 125 | HL patients: mean age 44.04 years, 52.7% NSHL, 17.7 MCHL, 6.8% NLPHL, 2% LRCHL, 19. UC. 69 males, 88 females. Geneotype data stratified by histopathology. | 125 | Mean age 58.3 years, 51 males, 60 females. |
| Hohaus S et al, 2003 | Italy |
GSTT1 GSTM1 |
Unspecified | 90 | HL patients: median age 33 years, 54 males, 36 females. 67 NSHL, 7 MCHL, 6 NLPHL, 1 LDHL, 9 UC. Geneotype data stratified by age and gender. | 176 | Matched for sex and age (69 females, 107 males; median age 38 years, range 19–71 years) |
| Cunningham L et al, 2003 | Australia | IL10 | Mixed | 44 | HL a subset of lymphoma cases. | 164 | Geographically and ethnically similar metropolitan population. |
| Sarmanova J et al, 2001 | Norway |
GSTP1 GSTT1 GSTM1 |
Caucasian | 143 | HL a subset of lymphoma cases. Genotype data stratified by gender. | 455 | Similar gender and age distribution as overall lymphoma cohort. Staff from institute and nearby inhabitants of houses for elderly citizens. |
| Gonzalez Ordonez A et al, 2000 | Spain | MTHFR | Unspecified | 29 | HL a subset of lymphoma cases. Mean age 24 years (SD 15 years). | 200 | Healthy Spanish volunteers. |
| Lemos M et al, 1999 | Portugal | GSTM1 | Portuguese | 25 | HL a subset of lymphoma cases. | 128 | Unrelated Portuguese Caucasian volunteers; 56 males, 72 females; no history of cancer or other chronic disease; no age-matching. |
HL, Hodgkin Lymphoma; SD, standard deviation; EBV, Epstein-Barr Virus; cHL, Classical Hodgkin Lymphoma; NSHL, nodular sclerosis Hodgkin Lymphoma; MCHL, mixed cellularity Hodgkin Lymphoma; LRHL, lymphocyte-rich Hodgkin-Lymphoma; LDHL, lymphocyte-depleted Hodgkin-Lymphoma; NLPHL, nodular lymphocyte-predominant Hodgkin-Lymphoma; UC, unclassified