Table 3. Summary of odds ratios of individual studies along with their confidence intervals.
| Heterozygous model |
Homozygous model |
Carrier status |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 95% CIs |
95% CIs |
95% CIs |
|||||||||||
| Study | Polymorphism | OR | Upper | Lower | P | OR | Upper | Lower | P | OR | Upper | Lower | P |
| Yri | IL-10, rs1800890 | 0.95 | 1.30 | 0.69 | 0.74 | 1.41 | 2.17 | 0.94 | 0.12 | 1.04 | 1.40 | 0.77 | 0.80 |
| Nieters | IL-10, rs1800890 | 1.07 | 1.63 | 0.7 | 0.77 | 0.63 | 1.29 | 0.19 | 0.20 | 0.96 | 1.45 | 0.64 | 0.86 |
| Nieters | IL10, rs1800896 | 0.96 | 1.51 | 0.61 | 0.86 | 0.62 | 1.14 | 0.15 | 0.12 | 0.85 | 1.30 | 0.55 | 0.45 |
| Munro | IL10, rs1800896 | 0.84 | 1.48 | 0.47 | 0.54 | 0.83 | 1.68 | 0.44 | 0.61 | 0.84 | 1.43 | 0.49 | 0.51 |
| Cunningham | IL10, rs1800896 | 0.92 | 2.00 | 0.43 | 0.84 | 0.54 | 1.49 | 0.18 | 0.23 | 0.79 | 1.66 | 0.38 | 0.54 |
| Cordano | IL6, rs1800795 | 0.85 | 1.17 | 0.61 | 0.32 | 1.03 | 1.58 | 0.19 | 0.88 | 0.89 | 1.21 | 0.66 | 0.47 |
| Cozen | IL6, rs1800795 | 0.58 | 1.13 | 0.30 | 0.11 | 0.35 | 0.95 | 0.14 | 0.04 | 0.52 | 0.98 | 0.27 | 0.04 |
| Yri | GSTP1, rs1695 | 0.85 | 1.17 | 0.62 | 0.32 | 1.33 | 2.03 | 0.24 | 0.19 | 0.96 | 1.28 | 0.71 | 0.76 |
| Lourenco | GSTP1, rs1695 | 0.34 | 0.57 | 0.20 | 0.00 | 0.58 | 1.13 | 0.04 | 0.11 | 0.39 | 0.63 | 0.25 | 0.00 |
| Ribrag | GSTP1, rs1695 | 1.01 | 1.49 | 0.68 | 0.97 | 1.06 | 1.90 | 0.66 | 0.85 | 1.02 | 1.47 | 0.71 | 0.92 |
| Sarmanova | GSTP1, rs1695 | 0.77 | 1.33 | 0.44 | 0.35 | 1.88 | 3.70 | 0.38 | 0.06 | 1.00 | 1.61 | 0.61 | 0.98 |
| Yri | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 3.17 | 5.09 | 1.97 | 0.00 |
| Ruiz-Cosano | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 2.95 | 7.96 | 1.10 | 0.03 |
| Ribrag | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.90 | 1.47 | 0.55 | 0.67 |
| Lourenco | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.92 | 1.65 | 0.51 | 0.78 |
| Hohaus | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 1.90 | 3.46 | 1.04 | 0.03 |
| Sarmanova | GSTT1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.88 | 1.79 | 0.43 | 0.72 |
| Yri | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 1.18 | 1.57 | 0.88 | 0.27 |
| Ruiz-Cosano | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.53 | 1.34 | 0.21 | 0.18 |
| Ribrag | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.83 | 1.2 | 0.58 | 0.33 |
| Lourenco | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 1.35 | 2.14 | 0.86 | 0.19 |
| Hohaus | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.75 | 1.25 | 0.45 | 0.26 |
| Sarmanova | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.90 | 1.45 | 0.55 | 0.66 |
| Lemos | GSTM1, deletion | NA | NA | NA | NA | NA | NA | NA | NA | 0.93 | 2.20 | 0.39 | 0.87 |
| Ruiz-Cosano | XPG/ERCC5, rs17655 | 1.89 | 5.28 | 0.68 | 0.22 | 4.86 | 18.69 | 3.81 | 0.01 | 2.33 | 6.06 | 0.89 | 0.08 |
| El-Zein | XPG/ERCC5, rs17655 | 1.19 | 1.79 | 0.79 | 0.40 | 1.63 | 3.60 | 0.58 | 0.22 | 1.25 | 1.84 | 0.85 | 0.26 |
| Kasperzyk | MTHFR, rs1801133 | 0.76 | 1.03 | 0.56 | 0.08 | 0.96 | 1.52 | 0.16 | 0.87 | 0.80 | 1.06 | 0.60 | 0.13 |
| Timuragaoglu | MTHFR, rs1801133 | 1.15 | 2.77 | 0.48 | 0.75 | 0.55 | 2.87 | 0.42 | 0.48 | 1.02 | 2.38 | 0.44 | 0.96 |
| Deligezer | MTHFR, rs1801133 | 0.49 | 0.96 | 0.25 | 0.04 | 0.26 | 1.19 | 0.07 | 0.06 | 0.45 | 0.85 | 0.23 | 0.01 |
| Gonzales Ordonez | MTHFR, rs1801133 | 0.77 | 1.76 | 0.33 | 0.53 | 0.92 | 3.48 | 0.34 | 0.9 | 0.8 | 1.73 | 0.36 | 0.56 |
| Ruiz-Cosano | MTR, rs1805087 | 0.84 | 2.70 | 0.26 | 0.78 | 5.81 | 21.90 | 2.06 | 0.00 | 1.47 | 3.73 | 0.58 | 0.41 |
| Kasperzyk | MTR, rs1805087 | 0.93 | 1.26 | 0.68 | 0.65 | 0.60 | 1.22 | 0.16 | 0.16 | 0.88 | 1.18 | 0.66 | 0.41 |
| Monroy | COX2, rs20417 | 1.39 | 0.74 | 2.6 | 0.31 | 6.94 | 2.68 | 59.16 | 0.04 | 1.6 | 2.93 | 0.87 | 0.13 |
| Chang | COX2, rs20417 | 1.11 | 1.49 | 0.82 | 0.51 | 1.99 | 4.24 | 0.65 | 0.07 | 1.18 | 1.57 | 0.88 | 0.27 |
| Hoeft | COX2, rs20417 | 1.05 | 1.65 | 0.67 | 0.83 | NA | NA | NA | NA | 0.99 | 1.55 | 0.63 | 0.97 |
| Chang | COX2, rs689466 | 0.99 | 1.36 | 0.73 | 0.97 | 1.16 | 2.39 | 0.33 | 0.69 | 1.01 | 1.36 | 0.75 | 0.93 |
| Hoeft | COX2, rs689466 | 0.99 | 1.53 | 0.63 | 0.95 | 0.31 | 2.35 | 0.31 | 0.23 | 0.93 | 1.43 | 0.60 | 0.73 |
| Yri | UGT1A1, tandem repeat | 0.90 | 1.22 | 0.66 | 0.49 | 0.79 | 1.32 | 0.16 | 0.37 | 0.88 | 1.17 | 0.66 | 0.37 |
| Ribrag | UGT1A1, tandem repeat | 0.70 | 1.04 | 0.47 | 0.07 | 0.71 | 1.32 | 0.12 | 0.28 | 0.70 | 1.02 | 0.48 | 0.06 |
CI, confidence interval; OR, odds ratio