Skip to main content
. Author manuscript; available in PMC: 2018 Oct 8.
Published in final edited form as: Hematol Oncol. 2015 Jun 5;35(1):34–50. doi: 10.1002/hon.2235

Table 5. Pooled odds ratios of all the polymorphisms examined once in the literature and GWAS data with the false positive report probabilities (FPRP).

Power FPRP at prior probability of 0.001
Gene, variant Studies Cases Controls OR   P Phet  I2 OR=1.2 OR=1.5 OR=1.2 OR=1.5
TNFα, rs1800750 2 928 1345
GA vs GG 1.78 (0.34 – 9.19)   0.50 0.01 84% 0.32 0.42
AA vs GG
Carrier 1.78 (0.34 – 9.19)   0.50 0.01 84% 0.32 0.42
TNFα, rs1800629 2 987 1893
GA vs GG 1.14 (0.94 – 1.37)   0.19 0.66 0 0.71 1.00
AA vs GG 1.17 (0.74 – 1.87)   0.50 0.43 0 0.54 0.85
Carrier 1.14 (0.95 – 1.37)   0.15 0.81 0 0.71 1.00
FCGR2, rs1801274 3 1704 7938
CT vs CC 1.15 (1.00 - 1.31)   0.05 0.93 0 0.74 1.00
TT vs CC 1.07 (0.91 - 1.26)   0.40 0.37 0 0.92 1.00
Carrier 1.12 (0.99 - 1.27)   0.08 0.96 0 0.86 1.00
IL1A, rs1800587 2 977 1877
CT vs CC 0.85 (0.72 – 1.00)   0.05 0.87 0 0.59 1.00
TT vs CC 0.72 (0.54 – 0.96)   0.02 0.10 63% 0.70 0.99 1.00 1.00
Carrier 1.00 (0.60 – 1.67)   0.99 0.03 80% 0.94 1.00
IL1B, rs16944 2 981 1876
GA cs GG 1.03 (0.87 – 1.22)   0.73 0.17 47% 0.96 1.00
AA vs GG 1.36 (1.05 – 1.77)   0.02 0.329 9% 0.18 0.77 0.99 0.97
Carrier 1.09 (0.93 – 1.28)   0.30 0.41 0 0.88 1.00
IL-4 rs2243248 3 1685 7465
TG vs GG 0.97 (0.70 - 1.33)   0.83 0.04 70% 0.83 0.99
GG vs TT 0.88 (0.42 - 1.86)   0.50 0.44 0 1.00 1.00
Carrier 1.02 (0.86 – 1.20)   0.84 0.08 61% 0.98 1.00
IL-4 rs2243250 2 976 1318
CT vs CC 1.06 (0.87 - 1.28)   0.58 0.91 0 0.90 1.00
TT vs CC  1.17 (0.69 – 2.00)   0.57 0.08 68% 0.54 0.82
Carrier 1.29 (0.77 – 2.16)   0.33 0.05 75% 0.39 0.72
IL4A rs1801275 3 1565 6517
AG vs AA 0.87 (0.76 – 0.99)   0.03 0.0 0 0.74 1.00 0.98 0.97
GG vs AA 1.07 (0.80 -1.43)   0.65 0.29 18% 0.78 0.99
carrier 0.89 (0.79 – 1.01)   0.07 0.70 0 0.85 1.00
IL10, rs1800872 2 987 1893
CA vs CC 0.98 (0.82 – 1.16)   0.79 0.09 64% 0.97 1.00
AA vs CC 1.26 (0.82 – 1.93)   0.30 0.65 0 0.41 0.79
Carrier 1.00 (0.85 – 1.20)   0.96 0.16 49% 0.98 1..00
IL10RA, rs2229113 3 986 1890
CT vs CC 0.85 (0.72 – 1.01)   0.06 0.97 0 0.59 1.00
TT vs CC 0.81 (0.62 – 1.06)   0.12 0.88 0 0.40 0.96
Carrier 0.84 (0.72 – 0.99)   0.04 0.93 0 0.54 1.00 0.97 0.97
IL10RA, rs3135932 3 987 1893
AG vs AA 0.98 (0.82 – 1.16)   0.76 0.09 64% 0.97 1.00
GG vs AA 1.26 (0.82 – 1.93)   0.30 0.65 0 0.41 0.79
Carrier 1.26 (0.46 – 3.48)   0.65 <0.001 94% 0.46 0.63
IRF4, rs872071 3 1592 7442
AG vs GG 0.92 (0.81 – 1.04)   0.19 0.41 0 0.94 1.00
AA vs GG 0.88 (0.76 – 1.02)   0.09 0.39 0 0.77 1.00
Carrier 0.90 (0.80 – 1.02)   0.09 0.52 0 0.89 1.00
LTC4S, rs730012 3 1915 6778
CA vs AA 0.94 (0.84 – 1.06)   0.34 0.41 0 0.98 1.00
CC vs AA 0.97 (0.79 – 1.19)   0.75 0.44 0 0.93 1.00
CArrier 0.95 (0.85 – 1.06)   0.35 0.44 0 0.99 1.00
CXCL12, rs1801157 2 912 1308
GA vs GG 1.05 (0.87 – 1.23)   0.60 0.97 0 0.95 1.00
AA vs GG 1.26 (0.78 – 2.02)   0.34 0.43 0 0.42 0.77
Carrier 1.07 (0.89 – 1.28)   0.46 0.75 0 0.90 1.00
TLR1, rs5743551 2 985 1881
AG vs AA 0.90 (0.76 – 1.06)   0.21 0.12 59% 0.82 1.00
GG vs AA 1.02 (0.72 – 1.45)   0.91 0.95 0 0.82 0.98
Carrier 0.91 (0.77 – 1.07)   0.27 0.16 50% 0.57 0.74
TLR2, rs4696480 2 986 1982
TA vs TT 1.47 (0.89 – 2.45)   0.13 0.05 75% 0.22 0.53
AA vs TT 1.09 (0.86 – 1.37)   0.48 0.20 40% 0.80 1.00
Carrier 1.42 (0.85 – 2.37)   0.18 0.04 76% 0.26 0.59
TLR9, rs187084 2 986 1982
TC vs TT 0.97 (0.81 – 1.16)   0.71 0.63 0 0.95 1.00
CC vs TT 0.83 (0.65 – 1.04)   0.11 0.99 0 0.49 0.97
Carrier 0.93 (0.78 – 1.10)   0.72 0.34 0 0.90 1.00
TLR9, rs5743836 2 986 1982
TC vs TT 1.11 (0.91 – 1.34)   0.31 0.08 68% 0.79 1.00
CC vs TT 1.02 (0.80 – 1.30)   0.89 0.99 0% 0.91 0.99
Carrier 1.07 (0.89 – 1.23)   0.50 0.12 59% 0.95 1.00
GSTA1, rs3957357 3 1688 7403
CT vs CC 1.07 (0.91 – 1.25)   0.41 0.19 40% 0.93 1.00
TT vsCC 0.81 (0.55 – 1.19)   0.28 0.67 0 0.44 0.84
Carrier 1.04 (0.89 – 1.21)   0.62 0.23 33% 0.97 1.00
EPHX, rs1051740 2 953 1665
TC vs TT 0.98 (0.83 – 1.17)   0.83 0.28 14% 0.96 1.00
CC vs TT 2.76 (0.20 – 38.40)   0.45 <0.001 97% 0.27 0.33
Carrier 1.14 (0.97 – 1.35)   0.11 0.06 72% 0.72 1.00
EPHX, rs2234922 2 666 5652
AG vs AA 0.87 (0.73 – 1.03)   0.11 0.78 0 0.70 1.00
GG vs AA 0.93 (0.61 – 1.42)   0.73 0.34 0 0.70 0.94
Carrier 0.87 (0.73 – 1.03)   0.11 0.58 0
CYP2C9, rs1057910 2 1054 5570
AC vs AA 1.26 (1.02 – 1.54)   0.03 0.97 0 0.70 1.00 0.99 0.96
CC vs AA 1.33 (0.49 – 3.67)   0.58 0.31 4% 0.42 0.59
Carrier 1.30 (1.03 – 1.54)   0.03 0.87 0 0.18 0.95 0.93 0.72
CYP2C9, rs1799853 2 1059 5569
CT vs CC 1.28 (1.07 – 1.51)   0.01 0.21 38% 0.22 0.97 0.94 0.78
TT vs CC 0.34 (0.02 – 6.89)   0.48 0.04 75% 0.28 0.33
Carrier 1.24 (1.05 – 1.46)   0.01 0.41 0 0.35 0.99 1.00 0.99
XPA, rs1800975 2 896 1432
GA vs GG 0.92 (0.76 – 1.10)   0.37 0.13 57% 0.86 1.00
AA vs GG 3.60 (0.49 – 26.70)   0.21 0.01 86% 0.14 0.20
Carrier 1.02 (0.86 – 1.22)   0.25 0.06 72% 0.96 1.00
XPC, rs2228000 2 984 1878
GA vs GG 0.84 (0.71 – 1.00)   0.05 0.53 0 0.52 0.89
AA vs GG 0.89 (0.70 – 1.50)   0.47 0.14 46% 0.60 0.86
Carrier 0.85 (0.71 – 1.00)   0.05 0.99 0 0.59 1.00
XPC, rs2228001 2 1663 6637
GT vs TT 0.98 (0.86 – 1.12)   0.78 0.97 0 0.99 1.2
GG vs TT 1.01 (0.85 – 1.20)   0.93 0.33 10% 0.98 1.00
Carrier 0.99 (0.86 – 1.12)   0.84 0.88 0 0.91 1.00
ERCC1, rs3212986 3 1633 6715
CA vs CC 0.80 (0.69 – 0.91) 0.001 0.85 0 0.27 1.00 0.72 0.41
AA vs CC 0.87 (0.68 – 1.22)   0.28 0.22 35% 0.60 0.94
Carrier 0.81 (0.72 – 0.91) 0.001 0.98 0 0.32 1.00 0.56 0.28
XRCC1, rs1799782 2 1072 1436
CT vs CC 0.69 (0.28 – 1.71)   0.42 0.01 84% 0.35 0.53
TT vs CC 0.73 (0.26 – 2.10)   0.56 0.38 0 0.40 0.57
Carrier 0.66 (0.25 – 1.74)   0.42 0.01 86% 0.32 0.50
XRCC3, rs861539 3 912 1308
GA vs GG 0.97 (0.86 – 1.10)   0.68 0.30 17% 0.99 1.00
AA vs GG 1.05 (0.88 – 1.26)   0.57 0.74 0 0.92 1.00
Carrier 0.99 (0.88 – 1.12)   0.89 0.34 7% 1.00 1.00
COX2 rs5277 2 1334 1577
CG vs CC 1.07 (0.90 – 1.27)   0.45 0.36 0 0.91 1.00
GG vs CC 0.79 (0.50 – 1.25)   0.31 0.73 0 0.41 0.77
Carrier 1.01 (0.86 – 1.19)   0.92 0.69 0 0.98 1.00
ABCC2, rs17222723 3 1688 6517
AT vs TT 0.97 (0.79 – 1.20)   0.80 0.74 0 0.92 1.00
AA vs TT 2.02 (0.85 – 4.77)   0.11 0.19 40% 0.12 0.25
Carrier 1.01 (0.83 – 1.23)   0.94 0.95 0 0.96 1.00
NBN, rs1801282 2 1044 1435
CA vs CC 1.07 (0.89 – 1.29)   0.45 0.06 70% 0.95 1.00
AA cs CC 0.99 (0.61 – 1.60)   0.95 0.21 37% 0.76 0.75
Carrier 1.07 (0.89 – 1.27)   0.50 0.19 42% 0.71 0.95
TP53, rs104522 2 1174 1967
GC vs CC 1.12 (0.96 – 1.30)   0.16 0.65 0 0.81 1.00
GG vs CC 0.96 (0.71 – 1.29)   0.76 0.54 0 0.83 0.99
Carrier 1.09 (0.94 – 1.26)   0.25 0.57 0
NFKB1, rs3774937 2 1041 5565
TC vs TT 1.02 (0.86 – 1.18)   0.92 0.65 0 0.90 1.00
CC vs TT 1.13 (0.90 – 1.44)   0.29 0.46 0 0.69 0.99
Carrier 0.85 (0.56 – 1.30)   0.45 0.01 86% 0.54 0.87
NFKB1A, rs696 2 1052 5563
AG vs GG 1.24 (1.06 – 1.45)   0.01 0.56 0 0.34 0.99 0.95 0.88
AA vs GG 1.40 (1.12 – 1.74) 0.003 0.25 23% 0.08 0.733 0.97 0.77
Carrier 1.27 (1.10 – 1.48) 0.002 0.35 0 0.23 0.98 0.90 0.70
NFKB1A, rs8904 2 1046 5566
CT cs CC 1.13 (0.96 – 1.32)   0.14 0.20 40% 0.78 1.00
TT vs CC 1.11 (0.89 – 1.39)   0.36 0.05 75% 0.77 1.00
Carrier 1.12 (0.97 – 1.31)   0.13 0.08 67% 0.81 1.00
NFKB1A, rs1050851 2 1331 1579
CT vs CC 0.87 (0.50 – 1.48)   0.60 0.002 90% 0.56 0.84
TT vs CC 0.88 (0.61 – 1.28)   0.51 0.52 0 0.61 0.93
Carrier 0.87 (0.52 – 1.44)   0.58 0.002 89% 0.57 0.85
NFKB1A, rs19571006
AT vs AA 1.09 (0.93 – 1.27)   0.30 0.90 0 0.89 1.00
TT vs AA 1.29 (0.67 – 2.48)   0.45 0.04 75% 0.41 0.67
Carrier 1.09 (0.94 – 1.27)   0.24 0.61 0 0.89 1.00
CHUK, rs2230804 2 1339 1577
AG vs AA 0.81 (0.54 – 1.24)   0.33 0.03 78% 0.45 0.82
GG vs AA 0.75 (0.48 – 1.17)   0.21 0.04 75% 0.32 0.70
Carrier 0.80 (0.52 – 1.22)   0.29 0.02 82% 0.43 0.80
PTGES, rs10448290 2 986 1884
AC vs AA 0.99 (0.80 – 1.23)   0.93 0.79 0 0.94 1.00
CC vs AA 1.42 (0.61 – 3.31)   0.41 0.06 71% 0.35 0.55
Carrier 1.01 (0.81 – 1.24)   0.96 0.48 0 0.95 1.00
PTGES, rs2241270 2 700 5866
AC vs AA 0.99 (0.82 – 1.20)   0.93 0.84 0 0.97 1.00
CC vs AA 0.90 (0.48 – 1.68)   0.73 0.77 0 0.60 0.83
Carrier 0.94 (0.82 – 1.18)   0.87 0.79 0 0.85 1.00
PTGES, rs4837404 2 1326 1579
AG vs AA 1.10 (0.94 – 1.29)   0.25 0.87 0 0.78 0.99
GG vs AA 1.08 (0.85 – 1.34)   0.51 0.41 0 0.83 1.00
Carrier 1.09 (0.94 – 1.27)   0.24 0.92 0 0.89 1.00
HPSE, rs4693608 3 1481 6520
GA vs GG 0.98 (0.84 – 1.14)   0.77 0.91 0 0.98 1.00
AA vs GG 0.98 (0.82 – 1.15)   0.70 0.88 0 0.98 1.00
Carrier  0.98 (0.85 – 1.13)   0.76 0.86 0 0.99 1.00
HPSE, rs11099592 3 1483 6520
GA vs GG 1.09 (0.96 – 1.24)   0.17 0.51 0 0.93 1.00
AA vs GG 0.87 (0.66 – 1.16)   0.35 0.30 16% 0.62 0.97
Carrier 1.06 (0.94 – 1.20)   0.34 0.39 0 0.98 1.00
HPSE, rs436425 2 607 5302
TC vs TT 1.00 (0.82 – 1.20)   0.97 0.60 0 0.98 1.00
CC vs TT 0.90 (0.66 – 1.23)   0.51 0.26 21% 0.69 0.97
Carrier 0.98 (0.83 – 1.16)   0.81 0.94 0 0.97 1.00
UGT1A6, rs1105879 3 1929 6774
TC vs CC 0.96 (0.85 – 1.08)   0.46 0.40 0 0.99 1.00
CC vs TT 1.02 (0.85 – 1.21)   0.87 0.74 0 0.97 1.00
Carrier 0.97 (0.87 – 1.09)   0.58 0.60 0 1.00 1.00
UGT1A6, rs2070959 3 1923 6785
AG vs AA 0.97 (0.86 – 1.09)   0.61 0.54 0 1.00 1.00
GG vs AA 1.07 (0.89 – 1.28)   0.49 0.66 0 0.86 1.00
Carrier 1.77 (0.56 – 5.52)   0.33 <0.001 99% 0.25 0.39

CI, confidence interval; OR, odds ratio