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. 2018 Aug 8;104(3):446–457. doi: 10.1002/cpt.1132

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© 2018 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Decision tree for botanical constituent(s). CAD, Charged Aerosol Detector; HRMS, High Resolution Mass Spectrometry; MoE, Margin of Exposure; MoS, Margin of Safety; SAR, structure‐activity relationship; TTC, threshold of toxicological concern; UHPLC, ultra‐high‐performance liquid chromatography. Reprinted from Food and Chemical Toxicology, Vol 107, Little, J., Marsman, D., Baker, T. & Mahony, C., In silico approach to safety of botanical dietary supplement ingredients utilizing constituent‐level characterization. 418–429, (C) 2017, with permission from Elsevier.