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. 2018 May 7;143(7):1696–1705. doi: 10.1002/ijc.31542

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© 2018 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Mutation landscape of lung adenocarcinoma in young never‐smoker patients. (a) Nonsynonynous mutation rates (number of mutations per Mb) in 36 tumor samples. (b) Genes predicted to be significantly mutated by MuSiC. Asterisk indicated that the genes were noted by both MuSiC and MutSigCV. Genes were sorted by significant FDR value (right panel); the frequency was indicated by the number of mutated samples (left panel). (c) Focal CNVs in known lung cancer genes in 36 tumor samples. (d) SVs previously implicated in lung cancer in 36 tumor samples. (e) Percentage of six types of single nucleotide substitutions in each tumor sample. The samples were ordered on the horizontal axis based on the clustering of their mutated genes. The colors denoted different types of somatic events. [Color figure can be viewed at http://wileyonlinelibrary.com]