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. 2018 May 27;16(7):1391–1401. doi: 10.1111/jth.14128

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© 2018 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Factor XIIIA activity assays. The activity of the full length rFXIIIA and fragments TB1 (lacking barrel 2), TCC (lacking barrels 1 and 2), and TBS (lacking catalytic core and barrels 1 and 2) was investigated by their ability to incorporate either a2‐antiplasmin into plates coated with fibrinogen or 5‐(Biotinamido) pentylamine into plates coated with fibrin or casein (A). Additionally a smaller, 9 amino acid substrate was used to determine relative activity of each of the fragments (B). Results shown are mean values as a percentage of full length rFXIIIA ± SD (n = 3). FXIIIA, full length FXIII A subunit; TB1, full length FXIII A subunit lacking barrel 2; TBS, full length FXIII A subunit lacking barrels 1 and 2, and catalytic core; TCC, full length FXIII A subunit lacking barrels 1 and 2.