Table 1.
Final fluticasone furoate Pharmacokinetic Model: PK Parameter Estimates
| Combined Model Ln Estimates | Historical Model Ln Estimates | Model Parameter Estimates With Combined Dataset | Historical Model Parameter Estimates | |
|---|---|---|---|---|
| Parameter | (95%CI) | (95%CI) | (95%CI) | (95%CI) |
| CL/F (L/h) | 5.43 | 5.44 | 228 | 230 |
| (5.38 to 5.48) | (5.39 to 5.49) | (217 to 240) | (219 to 242) | |
| V2/F (L) | 0.31 | 0.31 | 1.36 | 1.36 |
| (Fixed) | (Fixed) | (Fixed) | (Fixed) | |
| Q/F (L/h) | 5.74 | 5.59 | 311 | 268 |
| (5.54 to 5.94) | (5.40 to 5.78) | (255 to 380) | (221 to 324) | |
| V3 /F (L) | 4.66 | 4.71 | 106 | 111 |
| (4.45 to 4.87) | (4.51 to 4.91) | (86 to 130) | (90.9 to 136) | |
| KA (h‐1) | –2.94 | –2.95 | 0.053 | 0.052 |
| (–3 to 2.88) | (–3.01 to 2.89) | (0.049 to 0.056) | (0.049 to 0.056) |
CL/F, inhaled clearance; V2/F, volume of central compartment; Q/F, intercompartmental clearance; V3/F, volume of peripheral compartment; KA, absorption rate; CI, confidence interval; Ln, Log transformed.