Table 2.
Final umeclidinium and vilanterol Pharmacokinetic Model: PK Parameter Estimates
| Parameter | Model Parameter Estimates With Combined Dataset (RSE%) | Historical Model Parameter Estimates (RSE%) |
|---|---|---|
| umeclidinium | ||
| CL/F (L/h) | 210 (2.9) | 218 (2.3) |
| V2/F (L) | 1170 (1.12) | 1160 (2.8) |
| Q/F (L/h) | 854 (5.4) | 873 (4.7) |
| V3 /F (L) | 16200 (7.28) | 30200 (22.1) |
| KA (h‐1) | 40.3 (300) | 39.1 (43.7) |
| vilanterol | ||
| CL/F (L/h) | 41.6 (1.5) | 40.9 (1.4) |
| V2/F (L) | 271 (2.1) | 268 (2.0) |
| Q/F (L/h) | 116 (4.4) | 118 (4.6) |
| V3 /F (L) | 1280 (4.6) | 1240 (6.3) |
| KA (h‐1) | 19.6 (9.5) | 18.8 (12.8) |
CL/F, inhaled clearance; V2/F, volume of central compartment; Q/F, intercompartmental clearance; V3/F, volume of peripheral compartment; KA, absorption rate; CI, confidence interval.