Table 1.

Examples of HSP90 client proteins that are downregulated at the protein level in response to PEITC categorized by their associated roles

Function	HSP90 Clients
Cell division cycle	CDC25,90 CYCLIN D1,91 CYCLIN B1,92 CDK1,90, 92 CDK4,92 CDK6,92 WEE174d
Apoptosis	BCL‐2,80, 92 BCL‐xL80, 81
Angiogenesis	HIF‐1α,93 VEGFR194
Invasion and metastasis	MMP2, 995
DNA damage response	SP1,3,4,94 DNMT1, 3A, 3B66
Proliferation and survival	HER2,56, 96 STAT3,96 RAF1,56 EGFR,96 AKT,70, 97 PDK195a