Scheme 2.

Synthesis of organelle‐targeted caged arachidonic acid and sphingosine derivatives. A) Synthesis of the alkyne‐containing click‐cage photocleavable group 1. B) Synthesis of caged arachidonic acid derivatives for mitochondrial (11), lysosomal (12), plasma membrane (13), and ER photorelease (14). C) Synthesis of caged sphingosine derivatives for mitochondrial (18), lysosomal (19), plasma membrane (20), and ER (21) photorelease. D) Functionalized azido compounds utilized for click reactions in (B) and (C) and click‐cage chloroformate 16 utilized in (C).