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. 2018 Apr 6;42(8):E186–E203. doi: 10.1111/aor.13120

Table 1.

Schedules for surgery and examinations in monkeys in pilot 1‐month study and pivotal 6‐month study

Six monkeys for 1‐month observation
Day −12 Day −5 Day 0 Day 15 or 16 Day 28 or 29 Day 39 or 40
No. 1–1# CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT #Film not at degeneration
No. 1–2# CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT #Film in choroid
No. 1–3 CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT
No. 1–4 CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT Space between film and RPE
No. 1–5 CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT Space between film and RPE
No. 1–6 CoCl2 injection VEP, fERG, OCT Implantation AfterCataract, VEP only Capsulectomy VEP, fERG, OCT
Eight monkeys for 6‐month observation
Day −16 Day −13 Day −5 Day 0 Day 19 Day 25,26 Day 81,82 Day 130,131 Day 133 Day 148,149 Day 165,166
Tests Tests Surgery Surgery Tests Tests* Tests* Surgery Tests* Tests*
No. 2–1# CoCl2 injection Implantation
#VEP amplitude not reduced in macular degeneration #Film relocated spontaneously
No. 2–2 CoCl2 injection Implantation Space
No. 2–3# CoCl2 injection Implantation Space No testing Space
#Film not at degeneration
No. 2–4 CoCl2 injection Implantation Space Space
No. 2–5 CoCl2 injection Implantation Capsulectomy
No. 2–6 CoCl2 injection Implantation Space Film removal
No. 2–7 CoCl2 injection Implantation Space Space Space Film removal
No. 2–8 CoCl2 injection Implantation Capsulectomy Space Space Space Film removal

Monkeys (No. with #) were excluded from VEP analysis based on the reason also marked with #.

Tests: visual evoked potential (VEP), focal electroretinography (fERG), and optical coherence tomography (OCT).

Tests*: VEP, fERG, OCT, and full‐field ERG.

Space indicates the space between film and retinal pigment epithelium (RPE) detected by OCT.

No testing on Day 148, 149 in No. 2–3# monkey is due to convulsion in anesthesia.