Table 3.
Statistical Analysis of Pomalidomide Plasma Pharmacokinetic Parameters With and Without Fluvoxamine
| Pharmacokinetic Parameter (Unit) | Treatment | n | Geometric Meana | Ratio (%) of Geometric Means | 90%CI of Ratio of Geometric Means |
|---|---|---|---|---|---|
| AUC0‐inf (ng·h/mL) | Administered with fluvoxamine | 14 | 1185.2 | 225.1 | (198.0‐257.0) |
| Administered alone | 15 | 526.5 | |||
| Cmax (ng/mL) | Administered with fluvoxamine | 14 | 60.8 | 123.7 | (116.5‐131.3) |
| Administered alone | 15 | 49.2 |
AUC0‐inf, area under the plasma concentration‐time curve from time 0 to infinity; CI, confidence interval; Cmax, maximum plasma drug concentration; n, number of subjects.
a
Geometric means from analysis of variance analysis.