Table 4.
Summary of Pomalidomide Plasma Pharmacokinetic Parameters by Smoking Status (Study A)
| Pomalidomide PK Parameters | Nonsmokers, n = 13 | Smokers, n = 14 |
|---|---|---|
| AUC0‐inf (ng·h/mL) | 684.4 (19.6) | 463.1 (32.5) |
| Cmax (ng/mL) | 56.3 (16.6) | 64.4 (18.7) |
| tmax (h)a | 3.0 (1.5, 6.0) | 1.8 (1.0, 3.0) |
| t1/2 (h) | 7.8 (18.3) | 4.8 (29.9) |
| CL/F (L/h) | 5.8 (19.6) | 8.6 (32.5) |
| Vz/F (L) | 65.8 (10.0) | 59.7 (24.9) |
Geometric mean (geometric CV%) data from descriptive statistics are presented.
AUC0‐inf, area under the plasma concentration‐time curve from time 0 to infinity; CL/F, apparent total plasma clearance; Cmax, maximum plasma drug concentration; n, number of subjects; t1/2, terminal half‐life; tmax, time to Cmax; Vz/F, apparent volume of distribution during the terminal phase when dosed orally.
a
Median (minimum, maximum).