Table 2.
Final Population Pharmacokinetic and Pharmacodynamic Parameters and Results of Bootstrap Replicates for Propranolol
| Original Data | 1000 Bootstrap Sample Data | |||
|---|---|---|---|---|
| Parameter | Estimate (%RSE) | Shrinkage (%) | Median | 95%CI |
| Pharmacokinetics | ||||
| CL/F (L/h) | 9.34 (13.7) | NA | 9.67 | 7.32‐13.0 |
| V/F (L) | 146 (26.8) | NA | 141 | 64.8‐228 |
| ka (h–1) | 1.03 fixed | NA | 1.03 fixed | NA |
| PowerAGE for CL/F | 1 fixed | NA | 1 fixed | NA |
| IIV CL/F (%) | 76.9 (29.3) | 5.9 | 75.5 | 50.7‐99.3 |
| Proportional error (%) | 34.0 (11.9) | 20.0 | 33.5 | 25.2‐42.8 |
| Pharmacodynamics | ||||
| Baseline | –4.64 (12.6) | NA | –5.02 | –8.20 to –3.89 |
| Slope | 2.64 (36.6) | NA | 2.84 | 0.909‐5.85 |
| Treatment duration (weeks) on baseline | 0.215 (14.4) | NA | 0.234 | 0.175‐0.373 |
| Gestational age (days) on baseline | 0.0583 (44.4) | NA | 0.0637 | 0.0223‐0.252 |
Baseline indicates intercept coefficient of logistic regression; CL/F, apparent oral clearance; IIV, interindividual variability; ka, absorption rate constant; NA, not applicable; PowerAGE for CL/F, power exponent of AGE for CL/F; RSE, relative standard error; slope, slope of drug effect; V/F, apparent volume of distribution.