Table 3.
Simulated Trough and Peak Propranolol Concentrations After 7 Days of Repeated Administrations of 3 mg/kg Daily, With Each Daily Dose Divided Into 2 Administrations
| Trough (ng/mL)b | Peak (ng/mL) | |||
|---|---|---|---|---|
| Dosing Intervala | Median | 90% PI | Median | 95% PI |
| 6 hours | 16.7 | 0.119‐142 | 84.3 | 28.3‐234 |
| 9 hours | 20.8 | 0.335‐150 | 75.4 | 25.6‐225 |
| 12 hours | 26.4 | 0.981‐159 | 69.3 | 23.9‐214 |
PI indicates prediction interval.
a
Dosing intervals between first and second administrations within the same day.
b
168 hours after the first dose.