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Echocardiography. In lira group, left ventricular mass index (LVMI) (A), left atrial dimension (LAD) (B) and E/e’ (C) decreased throughout the study period. Fraction shortening (FS) (D), left ventricular ejection fraction (LVEF) (E) and E/A ratio (F) did not change in any group. *P < 0.01, **P < 0.05 vs baseline. †P < 0.01 vs lira group
