Fig 2. The influence of mixing patterns on trends in prevalence of skin microfilariae during mass drug administration.

Lines represent results repeated simulations for a fixed annual biting that was tuned (given exposure heterogeneity k and assumed mixing pattern) to result in an average pre-control prevalence of about 50% in the population of age 5 and above. In each simulation, 7 mass drug administration (MDA) rounds are implemented at 65% coverage of the general population. Participation to MDA was assumed to be semi-systematic (some individuals are structurally more likely to participate that others). S4 Fig illustrates similar results for other pre-control endemicity levels and assumed patterns in MDA participation.